横浜市立大学大学院・医学研究科 生理学














主な業績
私が教授の高橋です。


Hirobumi Tada, Tomoyuki Miyazaki, Kiwamu Takemoto, Susumu jitsuki, Waki Nakajima, Mayu Koide, Naoko Yamamoto, Akiko Taguchi, Honami Kawai, Kasane Komiya, Kumiko Suyama, Hiroki Abe, Akane Sano and Takuya Takahashi.
Social isolation suppresses actin dynamics and synaptic plasticity through ADF/cofilin inactivation in the developing rat barrel cortex.
Scientific Reports, Article number: 8471 (2017) ,
doi
:10.1038/s41598-017-08849-3 .

Kiwamu Takemoto*, Hiroko Iwanari, Hirobumi Tada, Kumiko Suyama, Akane Sano, Takeharu Nagai, Takao Hamakubo, and Takuya Takahashi*
Optical inactivation of synaptic AMPA receptors erases fear memory.
Nature Biotechnology, 35(1);38-47, 2017 (*co-corresponding author)

Hirobumi Tada, Tomoyuki Miyazaki, Kiwamu Takemoto, Kenkichi Takase, Susumu Jitsuki, Waki Nakajima, Mayu Koide, Naoko Yamamoto, Kasane Komiya, Kumiko Suyama, Akane Sano, Akiko Taguchi, and Takuya Takahashi.
Neonatal isolation augments social dominance by altering actin dynamics in the medial prefrontal cortex.
PNAS,1606351113, 2016.10

Matsumoto T, Fujimori K, Andoh-Noda T, Ando T, Kuzumaki N, Toyoshima M, Tada H, Imaizumi K, Ishikawa M, Yamaguchi R, Isoda M, Zhi Zhou, Sato S, Kobayashi T, Ohtaka M, Nishimura K, Kurosawa H, Yoshikawa T, Takahashi T, Nakanishi M, Ohyama M, Hattori N, Akamatsu W, and Okano H.
Functional Neurons Generated from T Cell-Derived Induced Pluripotent
Stem Cells for Neurological Disease Modeling
Stem Cell Reports,
doi:10.1016/j.stemcr.2016.01.010.

Nakajima W, Jitsuki S, Sano A, Takahashi T.
Sustained Enhancement of Lateral Inhibitory Circuit Maintains Cross Modal Cortical Reorganization
PLoS One, 11(2):e0149068, 2016, Feb 10.

Jitsuki S, Nakajima W, Takemoto K, Sano A, Tada H, Takahashi-Jitsuki A, Takahashi T.
Nogo Receptor Signaling Restricts Adult Neural Plasticity by Limiting Synaptic AMPA Receptor Delivery.
Cerebral Cortex, 26(1);427+439, 2016

Tada H, Koide M, Ara W, Shibata Y, Funabashi T, Suyama K, Goto T, Takahashi T.
Estrous Cycle-Dependent Phasic Changes in the Stoichiometry of Hippocampal Synaptic AMPA Receptors in Rats.
Plos One,
;10(6):e0131359. , 2015 Jun 29.


Tada M, Uchida H, Maeda T, Konishi M, Umeda S, Terasawa Y, Nakajima S, Mimura M, Miyazaki T, Takahashi T.
Fear Conditioning Induced by Interpersonal Conflicts in Healthy Individuals.
Plos One, Published: May 15, 2015. DOI: 10.1371/journal.pone.0125729

Uchimoto K, Miyazaki T, Kamiya Y, Mihara T, Koyama Y, Taguri M, Inagawa G,
Takahashi T, Goto T.
Isoflurane impairs learning and hippocampal long-term potentiation via the saturation of synaptic plasticity.
Anesthesiology, 121(2) : 302-10, 2014 

Mitsushima D, Sano A, Takahashi T.
A cholinergic trigger drives learning-induced plasticity at hippocampal synapses.
Nature Communications, Vol 4, Article number 2760, 2013.

Tada H, Kuroki Y, Funabashi T, Kamiya Y, Goto T, Suyama K, Sano A, Mitsushima D, Etgen AM, Takahashi T
Phasic synaptic incorporation of GluR2-lacking AMPA receptors at gonadotropin-releasing hormone neurons is involved in the generation of the luteinizing hormone surge in female rats.
Neuroscience. 248, 664-669, 2013.

Miyazaki T, Kunii M, Jitsuki S, Sano A, Kuroiwa Y, Takahashi T.
Social isolation perturbs experience-driven synaptic glutamate receptor subunit 4 delivery in the developing rat barrel cortex.
Eur J Neurosci. 37(10):1602-9, 2013.

Miyazaki T, Takase K, Nakajima W, Tada H, Ohya D, Sano A, Goto T, Hirase H,
Malinow R, Takahashi T.
Disrupted cortical function underlies behavior dysfunction due to social isolation.
122(7), 2690-701,2012.

Miyazaki T, Kunii M, Tada H, Sano A, Kuroiwa Y, Goto T, Malinow R, Takahashi T.
Developmental AMPA receptor subunit specificity during experience-driven synaptic plasticity in the rat barrel cortex.
Brain Res. 1435, 1-7. 2012.

Takahahi T
Serotonin as a mediator of cross-modal cortical reorganization.
Commun Integr Biol. 4(4), 45-461, 2011.

Mitsushima D, Ishihara K, Sano A, Kessels HW, Takahashi T.
Contaxtual learning requires synaptic AMPA receptor delivery in the hippocampus.
Proc Natl Acad Sci USA, 108(30), 12503-12508, 2011.

Jitsuki S, Takemoto K, Kawasaki T, Tada H, Takahashi A, Becamel C, Sano A, Yuzaki M, Zukin RS, Ziff EB, Kessels HW, and Takahashi T.
Serotonin mediates cross-modal reorganization of cortical circuits.
Neuron, 69, 780-792, 2011.  

Tada H, Okano HJ, Takagi H, Shibata S, Yao I, Matsumoto M, Saiga T, Nakayama KI, Kashima H, Takahashi T, Setou M, Okano H
"Fbxo45, a novel ubiquitin ligase, regulates synaptic activity."
J. Biol. Chem., 285(6):3840-9, 2010.

Mitsushima D, Takase K, Takahashi T, Kimura F.
Activational and organizational effects of gonadal steroids on sex-specific acetylcholine release in the dorsal hippocampus.

J Neuroendocrinol
,
21(4):400-405,2009.

Jitsuki S, Kimura F, Funabashi T, Takahashi T, Mitsushima D.
Sex-specific 24-h profile of extracellular serotonin levels in the medial prefrontal cortex.
Brain Res, 1260: 30-37, 2009.

Murota Y, Fujii M, Sugiyama Y, Funabashi T, Yagami T, Takahashi T,
Goshima, Y.
DOPA cyclohexyl ester, a DOPA antagonist, blocks the depressor responses elicited by microinjections of nicotine into the nucleus tractus solitarii of rats.
Neurosci Lett. 12;442(2):114-7, 2008.

Yamashita N, Morita A, Uchida Y, Nakamura F, Usui H, OhshimaT, Taniguchi M, Honnorat J, Thomasset N, Takei K, Takahashi T, Kolattukudy P, Goshima Y.
Regulation of spine development by semaphorin3A through cyclin-dependent kinase 5 phosphorylation of collapsin response mediator protein 1.
J. Neurosci. 14;27(46):12546-54, 2007.

Yamashita N, Uchida Y, Oshima T, Hirai S, Nakamura F, Taniguchi M, Mikoshiba K, Honnorat J, Kolattukudy P, Thomasset N, Takei K, Takahashi T, Goshima Y. 
Collapsin response mediator protein1 mediates reelin signaling in cortical neuronal migration. 
J. Neurosci. 26; 13357-13362, 2006.

Takahashi T, Svoboda K, Malinow R. 
Experience strengthening transmission by driving AMPA receptors into synapses. 
Science 299; 1585-1588, 2003.

Takahashi T, Strittmatter S.M. 
PlexinA1 auto-inhibition by the Plexin sema domain. 
Neuron 29; 429-439, 2001.

Tomoda A, Mori K, Kimura M, Takahashi T, Kitamura T. 
One-year prevalence and incidence of depression among first-year university students in Japan: a preliminary study. Psychiatry Clin. 
Neurosci. 54; 583-588. 2000.

Goshima Y, Hori H, Sasaki Y, Yang T, Kagoshima-Maezono M, Li C, Takenaka T Nakamura F, Takahashi T, Strittmatter S.M, Misu Y, Kawakami T. 
Growth cone neuropilin-1 mediates collapsin-1/semaIII Fasciliataion of antero- and retrograde axoplasmic transport. 
J. Neurobiol. 39; 579-589, 1999.

Takahashi T, Fournier A, Nakamura F, Wang L.-H, Murakami Y, Kalb R.G, Fujisawa H, Strittmatter S.M. 
Plexin-1-neuropilin-1 complexes form functional semaphoring-3A receptors. 
Cell 99; 59-69, 1999.

Nakamura F, Tanaka M, Takahashi T, Kalb R. G, Strittmatter S.M. 
Neuropilin-1 extracellular domains mediate semaphoring D/III-induced growth cone collapse. 
Neuron 21; 1093-1100, 1998.

Takahashi T, Nakamura F, Jin J, Kalb R.G, Strittmatter S.M. 
Semaphorin A and E act as antagonists of neuropilin-1 and agonists of neuropilin-2 receptors. 
Nature Neurosci. 1; 487-493, 1998.

Takahashi T, Nakamura F, Strittmatter S.M. 
Neuronal and non-neuronal collapsin-1 binding sites in developing chick are distinct from other semaphoring binding sites. 
J. Neurosci. 17; 9183-9193, 1997.

Okano H, Yoshikawa S, Suzuki A, Ueno N, Kaizu M, Okabe M, Takahashi T, Matsumoto M, Sawamoto K, Mikoshiba K. 
Cloning of a Drosophila  melanogaster  homologue of the mouse type-I bone morphogenetic proteins -2/-4 receptor: a potential decapentaplegic receptor. 
Gene 148; 203-209, 1994.

Matsuo K, Clay O, Takahashi T, Silke J, Schaffner W. 
Evidence for erosion Of mouse CpG islands during mammalian evolution. 
Som. Cell &Mol. Genet.19; 543-555, 1993.