• Yuki Katsuno, Susumu Jitsuki, Wataru Ota, Tomomi Yamanoue, Hiroki Abe, and Takuya Takahashi*
  Edonerpic maleate prevents epileptic seizure during recovery from brain damage by balancing excitatory and inhibitory inputs
  Frontiers in Neural Circuits.Volume 18, doi.org/10.3389/fncir.2024.1492043, Dec 06, 2024.
  
• Taisuke Yatomi,Dardo Tomasi, Hideaki Tani, Shinichiro Nakajima, Sakiko Tsugawa, Nobuhiro Nagai,Teruki Koizumi, Waki Nakajima, Mai Hatano, Hiroyuki Uchida and Takuya Takahashi*
  α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor density underlies intraregional and interregional functional centrality
  Frontiers in Neural Circuits.Volume 18, doi:org/10.3389/fncir.2024.1497897, Nov 06, 2024.
  
• Mai Hatano, Waki Nakajima, Hideaki Tani, Hiroyuki Uchida, Tomoyuki Miyazaki, Tetsu Arisawa, Yuuki Takada, Sakiko Tsugawa, Akane Sano, Kotaro Nakano, Tsuyoshi Eiro, Hiroki Abe, Akira Suda, Takeshi Asami, Akitoyo Hishimoto, Nobuhiro Nagai, Teruki Koizumi, Shinichiro Nakajima, Shunya Kurokawa, Yohei Ohtani, Kie Takahashi, Yuhei Kikuchi, Taisuke Yatomi, Shiori Honda, Masahiro Jinzaki, Yoji Hirano, Ryo Mitoma, Shunsuke Tamura, Shingo Baba, Osamu Togao, Hirotaka Kosaka, Hidehiko Okazawa, Yuichi Kimura, Masaru Mimura & Takuya Takahashi
  Characterization of patients with major psychiatric disorders with AMPA receptor positron emission tomography
  Molecular Psychiatry. OCt 15, 2024.
  
• 永露 毅, 宮崎 智之, 波多野 真依, 中島 和希, 有澤 哲, 高田 由貴, 木村 キミト, 野田 賀大, 内田 裕之, 木村 裕一 高橋 琢哉
  てんかん病態を制御する脳内AMPA受容体の動態
  核医学技術 43(予稿集) 321-321 2023年10月
  
• Nami Masumoto, Shingo Kato, Masahiro Aichi, Sho Hasegawa, Kota Sahara, Kumiko Suyama, Akane Sano, Tomoyuki Miyazaki, Koji Okudela, Takeshi Kaneko, Takuya Takahashi
  AMPAR receptor inhibitors suppress proliferation of human small cell lung cancer cell lines
  Thorac Cancer. doi: 10.1111/1759-7714.15075, Aug 22, 2023.
  
• Tsuyoshi Eiro, Tomoyuki Miyazaki, Mai Hatano, Waki Nakajima, Tetsu Arisawa, Yuuki Takada, Kimito Kimura, Akane Sano, Kotaro Nakano, Takahiro Mihara, Yutaro Takayama, Naoki Ikegaya, Masaki Iwasaki, Akitoyo Hishimoto, Yoshihiro Noda, Takahiro Miyazaki, Hiroyuki Uchida, Hideaki Tani, Nobuhiro Nagai, Teruki Koizumi, Takuya Takahashi
  Dynamics of AMPA receptors regulate epileptogenesis in patients with epilepsy
  Cell reports Medicine. 4, 101020, doi.org:10.1016 May 16, 2023.
  
• Tetsu Arisawa, Kimito Kimura, Tomoyuki Miyazaki, Yuuki Takada, Waki Nakajima, Wataru Ota, Sadamitsu Ichijo, Akane Sano, Yuuka Hirao , Jun-Ichi Kurita, Yoshifumi Nishimura, Takuya Takahashi
  Synthesis of [ 18 F] fluorine-labeled K-2 derivatives as radiotracers for AMPA receptors
  Nuclear Medicine and Biology.110-111:47-58. doi: 10.1016/j.nucmedbio.2022.04.009. Jul-Aug 2022.
  
• Kengo Yonezawa, Hideaki Tani, Shinichiro Nakajima, Nobuhiro Nagai, Teruki Koizumi, Tomoyuki Miyazaki, Masaru Mimura, Takuya Takahashi , Hiroyuki Uchida
  AMPA receptors in schizophrenia: A systematic review of postmortem studies on receptor subunit expression and binding
  Schizophrenia Research, Vol.243, 98-109, May 2022.
  
• Tomoyuki Miyazaki, Yutaro Takayama, Masaki Iwasaki , Mai Hatano, Waki Nakajima, Naoki Ikegaya, Tetsuya Yamamoto, Shohei Tsuchimoto, Hiroki Kato,Takuya Takahashi
  Epileptic discharges initiate from brain areas with elevated accumulation of α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors
  Brain Communications.4(2):fcac023. doi: 10.1093/Feb, 2022
  
• Tetsu Arisawa, Tomoyuki Miyazaki, Wataru Ota, Akane Sano, Kumiko Suyama, Yuuki Takada, Takuya Takahashi
  [11C]K-2 image with positron emission tomography represents cell surface AMPA receptors
  Neuroscience Research. 173:106-113. Dec, 2021.
  
• Kawashima T, Jitsuki-Takahashi A, Takizawa K, Jitsuki S, Takahashi T, Ohshima T, Goshima Y, Nakamura F
  Phosphorylation of Collapsin Response Mediator Protein 1 (CRMP1) at Tyrosine 504 residue regulates Semaphorin 3A-induced cortical dendritic growth.
  Journal of Neurochemistry. 2021.1.15
  doi.org/10.1111/jnc.15304
• Aoi Jitsuki-Takahashi Susumu Jitsuki Naoya Yamashita Meiko Kawamura Manabu Abe Kenji Sakimura Akane Sano Fumio Nakamura Yoshio Goshima Takuya TAKAHASHI
  Activity-induced secretion of semaphorin 3A mediates learning
  European Journal of Neuroscience
  First published: 26 March, 2021. Open Access
  https://doi.org/10.1111/ejn.15210
• Tomoyuki MIYAZAKI, Hiroki ABE, Hiroyuki UCHIDA, Takuya TAKAHASHI
  Translational medicine of the glutamate AMPA receptor
  Proceedings of the Japan Academy,Series B, 97-1, Review, 2021
  Online ISSN:1349-2896 Print ISSN:0386-2208, ISSN-L:0386-2208
• Mai Hatano, Tomoyuki Miyazaki*, Yoshinobu Ishiwata, Waki Nakajima, Tetsu Arisawa, Yoko Kuroki, Ayako Kobayashi, YuukiTakada, Matsuyoshi Ogawa, Kazunori Kawamura, Ming‑Rong Zhang, Makoto　Higuchi, MasatakaTaguri, Yasuyuki Kimura, Takuya Takahashi
  Biodistribution and radiation dosimetry of the positron emission tomography probe for AMPA receptor, [11C]K-2, in healthy human subjects
  Scientifc Reports 11:1598, 2021
• Miyazaki T, Nakajima W, Hatano M, Shibata Y, Kuroki Y, Arisawa T, Serizawa A, Sano A, Kogami SYamanoue T, Kimura K, Hirata Y, Takada Y, Ishiwata Y, Sonoda M, Tokunaga M, Seki C, Nagai　Y,Minamimoto T, Kawamura K, M.R. Zhang, Ikegaya N, Iwasaki M, Kunii N,Kimura Y, Yamashita F, Taguri M, Mimura M, Yuzaki M, Kato H, Higuchi M, Uchida H, Takahashi T
  Visualization of AMPA receptors in living human brain with positron emission tomography.
  Nature Medicine. 26,281-288, 2020. https://doi.org/10.1038/s41591-019-0723-9.
• Ueno F, Suzuki T, Nakajima S, Matsushita S, Mimura M, Miyazaki T, Takahashi T, Uchida H.
  Alteration in AMPA receptor subunit expression and receptor binding among patients with addictive disorders: A systematic review of human postmortem studies.
  Neuropsychopharmacology Reports, 39: 148-155. 2019.
• Trusel M, Nuno-Perez A, Lecca S, Harada H, Lalive AL, Congiu M, Takemoto K, Takahashi T,Ferraguti F, Mameli M.
  Punishment-Predictive Cues Guide Avoidance through Potentiation of Hypothalamus-to-Habenula Synapses.
  Neuron, 102, 1-8. 2019
• Tani H, Tada M, Maeda T, Konishi M, Umeda S, Terasawa Y, Mimura M, Takahashi T*, Uchida H*.
  Comparison of emotional processing assessed with fear conditioning by interpersonal conflicts in patients with depression and schizophrenia.
  Psychiatry and Clinical Neurosciences, 73(3):116-125.2019. (*co-corresponding author)
• Hiroki Abe#, Susumu Jitsuki#, Waki Nakajima#, Yumi Murata#, Aoi Jitsuki-Takahashi, Yuki Katsuno, Hirobumi Tada, Akane Sano, Kumiko Suyama, Nobuyuki Mochizuki, Takashi Komori, Hitoshi Masuyama, Tomohiro Okuda, Yoshio Goshima, Noriyuki Higo, Takuya TAKAHASHI.
  CRMP2-binding compound, edonerpic maleate, accelerates motor function recovery from brain damage.
  Science, 360: 50-57, 2018 (#equal contribution)
• Hirobumi Tada, Tomoyuki Miyazaki, Kiwamu Takemoto, Susumu jitsuki, Waki Nakajima, Mayu Koide, Naoko Yamamoto, Akiko Taguchi, Honami Kawai, Kasane Komiya, Kumiko Suyama, Hiroki Abe, Akane Sano and Takuya TAKAHASHI.
  Social isolation suppresses actin dynamics and synaptic plasticity through ADF/cofilin inactivation in the developing rat barrel cortex.
  Scientific Reports, 8471 (2017)
• Kiwamu Takemoto*, Hiroko Iwanari, Hirobumi Tada, Kumiko Suyama, Akane Sano, Takeharu Nagai, Takao Hamakubo, and Takuya TAKAHASHI*
  Optical inactivation of synaptic AMPA receptors erases fear memory.
  Nature Biotechnology, 35(1);38-47, 2017 (*co-corresponding author)
• Hirobumi Tada, Tomoyuki Miyazaki, Kiwamu Takemoto, Kenkichi Takase, Susumu Jitsuki, Waki Nakajima, Mayu Koide, Naoko Yamamoto, Kasane Komiya, Kumiko Suyama, Akane Sano, Akiko Taguchi, and Takuya TAKAHASHI.
  Neonatal isolation augments social dominance by altering actin dynamics in the medial prefrontal cortex.
  PNAS,1606351113, 2016
• Matsumoto T, Fujimori K, Andoh-Noda T, Ando T, Kuzumaki N, Toyoshima M, Tada H, Imaizumi K, Ishikawa M, Yamaguchi R, Isoda M, Zhi Zhou, Sato S, Kobayashi T, Ohtaka M, Nishimura K, Kurosawa H, Yoshikawa T, Takahashi T, Nakanishi M, Ohyama M, Hattori N, Akamatsu W, and Okano H.
  Functional Neurons Generated from T Cell-Derived Induced Pluripotent
  Stem Cells for Neurological Disease Modeling
  Stem Cell Reports, doi:10.1016/j.stemcr.2016.01.010.
• Nakajima W, Jitsuki S, Sano A, Takahashi T.
  Sustained Enhancement of Lateral Inhibitory Circuit Maintains Cross Modal Cortical Reorganization
  PLoS One, 11(2):e0149068, 2016, Feb 10.
• Jitsuki S, Nakajima W, Takemoto K, Sano A, Tada H, Takahashi-Jitsuki A, Takahashi T.
  Nogo Receptor Signaling Restricts Adult Neural Plasticity by Limiting Synaptic AMPA Receptor Delivery.
  Cerebral Cortex, 26(1);427+439, 2016
• Tada H, Koide M, Ara W, Shibata Y, Funabashi T, Suyama K, Goto T, Takahashi T.
  Estrous Cycle-Dependent Phasic Changes in the Stoichiometry of Hippocampal Synaptic AMPA Receptors in Rats.
  Plos One, ;10(6):e0131359. , 2015 Jun 29.
• Tada M, Uchida H, Maeda T, Konishi M, Umeda S, Terasawa Y, Nakajima S, Mimura M, Miyazaki T, Takahashi T.
  Fear Conditioning Induced by Interpersonal Conflicts in Healthy Individuals.
  Plos One, Published: May 15, 2015. DOI: 10.1371/journal.pone.0125729
• Uchimoto K, Miyazaki T, Kamiya Y, Mihara T, Koyama Y, Taguri M, Inagawa G, Takahashi T, Goto T.
  Isoflurane impairs learning and hippocampal long-term potentiation via the saturation of synaptic plasticity.
  Anesthesiology, 121(2) : 302-10, 2014
• Mitsushima D, Sano A, Takahashi T.
  A cholinergic trigger drives learning-induced plasticity at hippocampal synapses.
  Nature Communications, Vol 4, Article number 2760, 2013.
• Tada H, Kuroki Y, Funabashi T, Kamiya Y, Goto T, Suyama K, Sano A, Mitsushima D, Etgen AM, Takahashi T
  Phasic synaptic incorporation of GluR2-lacking AMPA receptors at gonadotropin-releasing hormone neurons is involved in the generation of the luteinizing hormone surge in female rats.
  Neuroscience. 248, 664-669, 2013.
• Miyazaki T, Kunii M, Jitsuki S, Sano A, Kuroiwa Y, Takahashi T.
  Social isolation perturbs experience-driven synaptic glutamate receptor subunit 4 delivery in the developing rat barrel cortex.
  Eur J Neurosci. 37(10):1602-9, 2013.
• Miyazaki T, Takase K, Nakajima W, Tada H, Ohya D, Sano A, Goto T, Hirase H, Malinow R, Takahashi T.
  Disrupted cortical function underlies behavior dysfunction due to social isolation.
  J Clin Invest. 122(7), 2690-701,2012.
• Miyazaki T, Kunii M, Tada H, Sano A, Kuroiwa Y, Goto T, Malinow R, Takahashi T.
  Developmental AMPA receptor subunit specificity during experience-driven synaptic plasticity in the rat barrel cortex.
  Brain Res. 1435, 1-7. 2012.
• Takahashi T
  Serotonin as a mediator of cross-modal cortical reorganization.
  Commun Integr Biol. 4(4), 45-461, 2011.
• Mitsushima D, Ishihara K, Sano A, Kessels HW, Takahashi T.
  Contaxtual learning requires synaptic AMPA receptor delivery in the hippocampus.
  Proc Natl Acad Sci USA, 108(30), 12503-12508, 2011.
• Jitsuki S, Takemoto K, Kawasaki T, Tada H, Takahashi A, Becamel C, Sano A, Yuzaki M, Zukin RS, Ziff EB, Kessels HW, and Takahashi T.
  Serotonin mediates cross-modal reorganization of cortical circuits.
  Neuron, 69, 780-792, 2011.
• Tada H, Okano HJ, Takagi H, Shibata S, Yao I, Matsumoto M, Saiga T, Nakayama KI, Kashima H, Takahashi T, Setou M, Okano H
  "Fbxo45, a novel ubiquitin ligase, regulates synaptic activity."
  J. Biol. Chem., 285(6):3840-9, 2010.
• Mitsushima D, Takase K, Takahashi T, Kimura F.
  Activational and organizational effects of gonadal steroids on sex-specific acetylcholine release in the dorsal hippocampus.
  J Neuroendocrinol, 21(4):400-405,2009.
• Jitsuki S, Kimura F, Funabashi T, Takahashi T, Mitsushima D.
  Sex-specific 24-h profile of extracellular serotonin levels in the medial prefrontal cortex.
  Brain Res, 1260: 30-37, 2009.
• Murota Y, Fujii M, Sugiyama Y, Funabashi T, Yagami T, Takahashi T, Goshima, Y.
  DOPA cyclohexyl ester, a DOPA antagonist, blocks the depressor responses elicited by microinjections of nicotine into the nucleus tractus solitarii of rats.
  Neurosci Lett. 12;442(2):114-7, 2008.
• Yamashita N, Morita A, Uchida Y, Nakamura F, Usui H, OhshimaT, Taniguchi M, Honnorat J, Thomasset N, Takei K, Takahashi T, Kolattukudy P, Goshima Y.
  Regulation of spine development by semaphorin3A through cyclin-dependent kinase 5 phosphorylation of collapsin response mediator protein 1.
  J. Neurosci. 14;27(46):12546-54, 2007.
• Yamashita N, Uchida Y, Oshima T, Hirai S, Nakamura F, Taniguchi M, Mikoshiba K, Honnorat J, Kolattukudy P, Thomasset N, Takei K, Takahashi T, Goshima Y.
  　 Collapsin response mediator protein1 mediates reelin signaling in cortical neuronal migration.
  J. Neurosci.26; 13357-13362, 2006.
• Takahashi T,Svoboda K, Malinow R.
  Experience strengthening transmission by driving AMPA receptors into synapses.
  Science 299; 1585-1588, 2003.
  
• Takahashi T, Strittmatter S.M.
  PlexinA1 auto-inhibition by the Plexin sema domain.
  Neuron 29; 429-439, 2001.
• Tomoda A, Mori K, Kimura M,Takahashi T, Kitamura T.
  One-year prevalence and incidence of depression among first-year university students in Japan: a preliminary study. Psychiatry Clin.
  Neurosci. 54; 583-588. 2000.
• Goshima Y, Hori H, Sasaki Y, Yang T, Kagoshima-Maezono M, Li C, Takenaka T Nakamura F, Takahashi T, Strittmatter S.M, Misu Y, Kawakami T.
  Growth cone neuropilin-1 mediates collapsin-1/semaIII Fasciliataion of antero- and retrograde axoplasmic transport.
  J. Neurobiol. 39; 579-589, 1999.
• Takahashi T, Fournier A, Nakamura F, Wang L.-H, Murakami Y, Kalb R.G, Fujisawa H, Strittmatter S.M.
  Plexin-1-neuropilin-1 complexes form functional semaphoring-3A receptors.
  Cell 99; 59-69, 1999.
• Nakamura F, Tanaka M, Takahashi T, Kalb R. G, Strittmatter S.M.
  Neuropilin-1 extracellular domains mediate semaphoring D/III-induced growth cone collapse.
  Neuron 21; 1093-1100, 1998.
• Takahashi T, Nakamura F, Jin J, Kalb R.G, Strittmatter S.M.
  Semaphorin A and E act as antagonists of neuropilin-1 and agonists of neuropilin-2 receptors.
  Nature Neurosci. 1; 487-493, 1998.
• Takahashi T, Nakamura F, Strittmatter S.M.
  Neuronal and non-neuronal collapsin-1 binding sites in developing chick are distinct from other semaphoring binding sites.
  J. Neurosci. 17; 9183-9193, 1997.
• Okano H, Yoshikawa S, Suzuki A, Ueno N, Kaizu M, Okabe M, Takahashi T, Matsumoto M, Sawamoto K, Mikoshiba K.
  Cloning of a Drosophila melanogaster homologue of the mouse type-I bone morphogenetic proteins -2/-4 receptor: a potential decapentaplegic receptor.
  Gene 148; 203-209, 1994.
• Matsuo K, Clay O, Takahashi T, Silke J, Schaffner W.
  Evidence for erosion Of mouse CpG islands during mammalian evolution.
  Som. Cell &Mol. Genet. 19; 543-555, 1993.