横浜市立大学大学院・医学研究科 生理学














教室員の紹介

貴邑冨久子 (田中冨久子)  きむらふくこ たなかふくこ

(主な業績)
Mitsushima D, Takase K, Takahashi T, Kimura F.
Activational and organizational effects of gonadal steroids on sex-specific acetylcholine release in the dorsal hippocampus.
J Neuroendocrinol, review article, in press, 2009.

Mitsushima D, Takase K, Funabashi T, Kimura F.
Gonadal steroids maintain 24-h acetylcholine release in the hippocampus: organizational and activational effects in behaving rats.
J Neurosci, 29: 3808-3815, 2009.

Takase K, Kimura F, Yagami T, Mitsushima D.
Sex-specific 24-h acetylcholine release profile in the medial prefrontal cortex: simultaneous measurement of spontaneous locomotor activity in behaving rats.
Neuroscience
, 159: 7-15, 2009.

Jitsuki S, Kimura F, Funabashi T, Takahashi T, Mitsushima D.
Sex-specific 24-h profile of extracellular serotonin levels in the medial prefrontal cortex.
Brain Res, 1260: 30-37, 2009.

Takase K, Mitsushima D, Funabashi T, Kimura F.
Postpubertal feeding experience affects sex-specific spatial ability in rats.
Physiol Behav, 93: 553-559, 2008.

Mitsushima D, Takase K, Funabashi T, Kimura F. 
Gonadal steroid hormones maintain the stress-induced acetylcholine release in the hippocampus: simultaneous measurements of the extracellular acetylcholine and serum corticosterone levels in the same subjects. 
Endocrinology,149: 802-811, 2008.

Takase K, Mitsushima D, Funabashi T, Kimura F. 
Sex difference in the 24-h acetylcholine release profile in the premotor/supplementary motor area of behaving rats. 
Brain Res, 1154: 105-115, 2007.

Takase K, Mitsushima D, Funabashi T, Kimura F. 
Postpubertal feeding experience affects sex-specific spatial abililty in rats. 
Physiol Behav, 93: 553-559, 2007.

Fukushima A, Funabashi T, Kawaguchi M, Mitsushima D, Kimura F. 
Bisphenol A induces transforming growth factor-bata3 mRNA in the preoptic area: a cDNA expression array and northern blot study. 
Neurosci Lett, 411: 81-85, 2007.

Hagiwara H, Funabashi T, Mitsushima D, Kimura F. 
Effects of neonatal testosterone treatment on sex differences in formalin-induced nociceptive behavior in rats. 
Neurosci Lett, 412: 264-267, 2007.

Shimamura, M., Shimizu, M., Yagami, T., Funabashi, T., Kimura, F., Kuroiwa, Y., Misu, Y., Goshima, Y. 
l-3,4-Dihydroxyphenylalanine-induced c-Fos expression in the CNS under inhibition of central aromatic l-amino acid decarboxylase. 
Neuropharmacology, 50: 909-916, 2006.

Furuta, M., Funabashi, T., Kawaguchi, M., Nakamura, T.J., Mitsushima, D.,
and Kimura, F. 
Effects of p-Nonylphenol and 4-tert-Octylphenol on the Anterior Pituitary Functions in Adult Ovariectomized Rats. 
Neuroendocrinology, 84: 14-20, 2006.

Fukushima, A., Funabashi1, T., Kawaguchi, M., Mitsushima, D., and Kimura, F. 
Bisphenol A induces expression of transforming growth factor-b3 messenger ribonucleic acid in the medial preoptic area of adult ovariectomized rats as revealed by cDNA expression array. 
Neurosci Lett, 411: 81-85, 2006. 

Mitsushima, D., Yamada, K., Takase, K., Funabashi. T., and Kimura, F. 
Sex differences in the basolateral amygdala: the extracellular level of serotonin and dopamine and their responses to restraint stress in rats. 
Eur J Neurosci, 24: 3245-3254, 2006.

Masuda, J., Mitsushima, D., Funabashi, T., and Kimura, F. 
Sex and housing conditions affect the 24-h acetylcholine release profile in the hippocampus in rats. 
Neuroscience, 132: 537-542, 2005.

Funabashi, T., Sano, A., Mitsushima, D., and Kimura, F. 
Nicotine inhibits pulsatile luteinizing hormone secretion in human males but not in human females, and tolerance to this nicotine effect is lost within one week of quitting smoking. 
J Clin Endocrinol Metab, 90: 3908-3931, 2005.

Mogi, K., Funabashi, T., Mitsushima, D., Hagiwara, H., and Kimura. F. 
Sex difference in the response of melanin-concentrating hormone neurons in the lateral hypothalamic area to glucose, as revealed by the expression of phosphorylated cyclic adenosine 3',5'-monophosphate response element-binding protein. 
Endocrinology, 146: 3325-3333, 2005.

Takase, K., Funabashi, T., Mogi, K., Mitsushima, D., and Kimura, F. 
Feeding with powdered diet after weaning increases visuospatial ability in association with increases in the expression of N-methyl-d-aspartate receptors in the hippocampus of female rats. 
Neurosci Res, 53: 169-175, 2005.

Takase, K., Mitsushima, D., Masuda, J., Mogi, K., Funabashi, T., Endo, Y., and Kimura, F. 
Feeding with powdered diet after weaning affects sex difference in acethylcholine release in the hippocampus in rats. 
Neuroscience, 136: 593-599, 2005.

Funabashi, T., Kawaguchi, M., Furuta, M., Fukushima, A., and Kimura, F. 
Exposure to bisphenol A during gestation and lactation causes loss of sex difference in corticotropin-releasing hormone-immunoreactive neurons in the bed nucleus of the stria terminalis of rats. 
Psychoneuroendocrinology, 29: 475-485, 2004.

Funabashi, T., Nakamura, T.J., and Kimura, F.
p-Nonylphenol, 4-tert-octylphenol and bisphenol A increase the expression of progesterone receptor mRNA in the frontal cortex of adult ovariectomized rats. 
J Neuroendocrinol, 16: 99-104, 2004.

Kimura, F., Shinohara, K., Funabashi, T., Daikoku, S., Suyama, K., Mitsushima, D., and Sano, A. 
Nicotine inhibition of pulsatile GnRH secretion is mediated by GABAA receptor system in the cultured rat embryonic olfactory placode. 
Psychoneuroendocrinology, 29: 749-756, 2004.

Suyama, K., Daikoku, S., Funabashi, T., and Kimura, F. 
Effects of GABA and bicuculline on the electrical activity of rat olfactory placode neurons derived at E13.5 and cultured for 1 week on multi-electrode dishes. 
Endocr J, 51: 171-176, 2004.

Quan, H., Funabashi, T., and Kimura, F. 
Intracerebroventricular injection of corticotropin-releasing hormone receptor antagonist blocks the suppression of pulsatile luteinizing hormone secretion induced by neuromedin U in ovariectomized rats after 48 hours of fasting. 
Neurosci Lett, 369: 33-38, 2004.

Funabashi, T., Sano, A., Mitsushima, D., and Kimura, F. 
Bisphenol A increases progesterone receptor immunoreactivity in the hypothalamus in a dose-dependent manner and affects sexual behaviour in adult ovariectomized rats. 
J Neuroendocrinol, 15: 134-140, 2003.

Mitsushima, D., Funabashi, T., Shinohara, K., and Kimura, F. 
Rats living in small cages respond to restraint stress with adrenocortical corticosterone release but not with hippocampal acetylcholine release. Psychoneuroendocrinology, 28: 574-583, 2003.

Mitsushima, D., Funabashi, T., and Kimura, F. 
Estrogen increases messenger RNA and immunoreactivity of aryl-hydrocarbon receptor nuclear translocator 2 in the rat mediobasal hypothalamus. 
Biochem Biophy Res Comm, 307: 248-253, 2003.

Quan, H., Funabashi, T., Furuta, M., and Kimura, F. 
Effects of neuromedin U on the pulsatile LH secretion in ovariectomized rats in association with feeding conditions.
Biochem Biophy Res Comm., 311: 721-727, 2003.

Funabashi T, Sano A, Mitsushima D, Kimura F. 
Bisphenol A increases progesterone receptor immunoreactive cells in the hypothalamus in a dose-dependent manner and affects sexual behavior in adult ovariectomized rats. 
J Neuroendocrinology, 15: 134-140, 2003.

Mitsushima D, Funabashi T, Shinohara K, Kimura F. 
Rats living in small cages respond to restraint stress with adrenocortical corticosterone release but not with hippocampal acetylcholine release. 
Psychoneuroendocrinology, 28: 574-583, 2003.

Tin-Tin-Win-Shwe, Mitsushima D, Kimura F. 
Profiles of in vivo GABA release in the medial preoptic area of intact and castrated male rats. 
Neuroendocrinology, 76: 290-296, 2002.

Mitsushima D, Tin-Tin-Win-Shwe, Funabashi T, Shinohara K, Kimura F. 
GABA release in the medial preoptic area of cyclic female rats. 
Neuroscience, 113(1):109-114, 2002 . 
PMID: 12123689

Shinohara K, Funabashi T, Nakamura TJ, Mitsushima D, Kimura F. 
Differential regulation of pituitary adenyl cyclase activating peptide receptor variants in the rat suprachiasmatic nucleus. 
Neuroscience 2002;110(2):301-8. 
PMID: 11958871

Furuta M, Funabashi T, Kimura F. 
Suppressive Action of Orexin A on Pulsatile Luteinizing Hormone Secretion Is Potentiated by a Low Dose of Estrogen in Ovariectomized Rats. 
Neuroendocrinology. 2002 Mar;75(3):151-157.

Furuta M, Funabashi T, Kimura F. 
Intracerebroventricular administration of ghrelin rapidly suppresses pulsatile luteinizing hormone secretion in ovariectomized rats. 
Biochem Biophys Res Commun. 2001 Nov 9;288(4):780-5.

Nakamura TJ, Shinohara K, Funabashi T, Kimura F. 
Effect of estrogen on the expression of Cry1 and Cry2 mRNAs in the suprachiasmatic nucleus of female rats. 
Neurosci Res. 2001 Nov;41(3):251-5.

Mitsushima D, He D, Funabashi T, Shinohara K, Kimura F. 
Increase in the number of detectable preoptic GAD67 immunoreactive cells in immature male rats. 
Neurosci Res. 2001 May 40(2):141-146.

Mitsushima D, Funabashi T, Shinohara K, Kimura F. 
Impairment of maze learning in rats by restricting environmental space. 
Neurosci Lett. 2001 Jan 12;297(2):73-6.

Funabashi T, Suyama K, Uemura T, Hirose M, Hirahara F, Kimura F. 
Immortalized Gonadotropin-Releasing Hormone Neurons (GT1-7 Cells) Exhibit Synchronous Bursts of Action Potentials. 
Neuroendocrinology. 2001 Mar; 73(3): 157-165.

Shinohara K, Morofushi M, Funabashi T, Kimura F. 
Axillary pheromones modulate pulsatile LH secretion in humans. 
Neuroreport. 2001 Apr 17; 12(5): 893-5.

Sano A, Kimura F. 
Electrical activity of the pulse generator of gonadotropin-releasing hormone in 26-month-old female rats. 
Neuroendocrinology. 2000 Oct; 72(4): 199-207.

Funabashi T, Kleopoulos SP, Brooks PJ, Kimura F, Pfaff DW, Shinohara K, Mobbs CV. 
Changes in estrogenic regulation of estrogen receptor alpha mRNA and progesterone receptor mRNA in the female rat hypothalamus during aging: an in situ hybridization study. 
Neurosci Res. 2000, Sep; 38(1): 85-92.

Shinohara K, Funabashi T, Mitushima D, Kimura F. 
Effects of gap junction blocker on vasopressin and vasoactive intestinal polypeptide rhythms in the rat suprachiasmatic nucleus in vitro. 
Neurosci Res. 2000 Sep; 38(1): 43-7.

Shinohara K, Morofushi M, Funabashi T, Mitsushima D, Kimura F. 
Effects of 5alpha-androst-16-en-3alpha-ol on the pulsatile secretion of luteinizing hormone in human females. 
Chem Senses. 2000, Aug; 25(4) : 465-7.

Morofushi M, Shinohara K, Funabashi T, Kimura F. 
Positive relationship between menstrual synchrony and ability to smell 5alpha-androst-16-en-3alpha-ol. 
Chem Senses. 2000, Aug; 25(4 ):407-11.

Funabashi T, Shinohara K, Mitsushima D, Kimura F. 
Gonadotropin-releasing hormone exhibits circadian rhythm in phase with arginine-vasopressin in co-cultures of the female rat preoptic area and suprachiasmatic nucleus. 
J Neuroendocrinol. 2000, Jun; 12(6): 521-8.

Shinohara K, Funabashi T, Mitushima D, Kimura F. 
Effects of estrogen on the expression of connexin32 and connexin43 mRNAs in the suprachiasmatic nucleus of female rats. 
Neurosci Lett. 2000, Jun 2; 286(2): 107-10.

Funabashi T, Shinohara K, Mitsushima D, Kimura F. 
Estrogen increases arginine-vasopressin V1a receptor mRNA in the preoptic area of young but not of middle-aged female rats. 
Neurosci Lett. 2000 May 19;285(3):205-8.

Saito K, Shinohara K, Morofushi M, Funabashi T, Mitsushima D, Hata M, Matsubara S, Kimura F. 
Effects of irradiation on the sensitivity of melatonin release to norepinephrine in cultured pineal bodies of rats. 
Neurosci Lett. 2000 Apr 21;284(1-2):93-6.

Funabashi T, Jinnai K, Sano A, Shinohara K, Kimura F. 
Pentobarbital stimulates the activity of the GnRH pulse generator interacting with opioid neurons in rats in proestrus. 
Psychoneuroendocrinology. 2000 Apr;25(3):277-87.

Shinohara K, Hiruma H, Funabashi T, Kimura F. 
GABAergic modulation of gap junction communication in slice cultures of the rat suprachiasmatic nucleus. 
Neuroscience. 2000;96(3):591-6.

Shinohara K, Uchiyama M, Okawa M, Saito K, Kawaguchi M, Funabashi T, Kimura F. 
Menstrual changes in sleep, rectal temperature and melatonin rhythms in a subject with premenstrual syndrome. 
Neurosci Lett. 2000 Mar 10;281(2-3):159-62.

He D, Mitsushima D, Uemura T, Hirahara F, Funabashi T, Shinohara K, Kimura F. 
Effects of naloxone on the serum luteinizing hormone level and the number of Fos-positive gonadotropin-releasing hormone neurons in immature female rats. 
Brain Res. 2000 Mar 6;858(1):129-35.

Funabashi T, Daikoku S, Shinohara K, Kimura F. 
Pulsatile gonadotropin-releasing hormone (GnRH) secretion is an inherent function of GnRH neurons, as revealed by the culture of medial olfactory placode obtained from embryonic rats. 
Neuroendocrinology. 2000 Feb;71(2):138-44.

Akema T, Ikeda T, Chiba A, Sugiyama H, Sato I, Kimura F, Toyoda J. 
Intraventricular injection of melatonin inhibits naloxone-induced, but not NMDA- or LHRH-induced LH release in ovariectomized estrogen-primed rats. 
Endocr J. 1999, Dec; 46(6): 831-6.

Mitsushima D, Funabashi T, Kimura F. 
Fos expression in gonadotropin-releasing hormone neurons by naloxone or bicuculline in intact male rats. 
Brain Res. 1999, Aug 21; 839(1): 209-12.

Sano A, Funabashi T, Kawaguchi M, Shinohara K, Kimura F. 
Intravenous injections of nicotine decrease the pulsatile secretion of LH by inhibiting the gonadotropin-releasing hormone (GnRH) pulse generator activity in female rats. 
Psychoneuroendocrinology, 1999, May;24(4): 397-407.

Nishimura J, Endo Y, Kimura F. 
A long-term stress exposure impairs maze learning performance in rats. 
Neurosci Lett, 1999, Oct 1;273(2): 125-8.

Endo Y, Nishimura JI, Kobayashi S, Kimura F. 
Chronic stress exposure influences local cerebral blood flow in the rat hippocampus.
Neuroscience. 1999;93(2):551-5.

Funabashi T, Aiba S, Sano A, Shinohara K, Kimura F. 
Intracerebroventricular injection of arginine-vasopressin V1 receptor antagonist attenuates the surge of luteinizing hormone and prolactin secretion in proestrous rats. 
Neurosci Lett. 1999 Jan 22;260(1):37-40.

Gerkema MP, Shinohara K, Kimura F. 
Lack of circadian patterns in vasoactive intestinal polypeptide release and variability in vasopressin release in vole suprachiasmatic nuclei in vitro. 
Neurosci Lett. 1999 Jan 8;259(2):107-10.

He D, Funabashi T, Sano A, Uemura T, Minaguchi H, Kimura F. 
Effects of glucose and related substrates on the recovery of the electrical activity of gonadotropin-releasing hormone pulse generator which is decreased by insulin-induced hypoglycemia in the estrogen-primed ovariectomized rat. 
Brain Res. 1999 Feb 27;820(1-2):71-6.

Hla-Hla-Aye, Jinnai K, Sano A, Funabashi T, Mitsushima D, Kimura F. 
Nicotine given intracerebroventricularly does not inhibit the preovulatory surge of LH and PRL secretion in female rats. 
Endocr J. 1998 Aug;45(4):575-80.

Shinohara K, Funabashi T, Kimura F. 
Temporal profiles of vasoactive intestinal polypeptide precursor mRNA and its receptor mRNA in the rat suprachiasmatic nucleus. 
Brain Res Mol Brain Res. 1999 Jan 8;63(2):262-7.

Kawaguchi M, Funabashi T, Kimura F. 
Insulin-induced hypoglycemia does not impair the surge of luteinizing hormone secretion in the proestrous rat. 
Neurosci Lett. 1998 Nov 13;256(3):131-4.

Funabashi T, Kleopoulos SP, Kimura F, Mobbs CV. 
Changes in neurotensin mRNA by estrogen in the female rat preoptic area during aging: an in situ hybridization histochemistry study. 
Gen Comp Endocrinol. 1998 Dec;112(3):364-71.

Mitsushima D, Yamanoi C, Kimura F. 
Restriction of environmental space attenuates locomotor activity and hippocampal acetylcholine release in male rats. 
Brain Res. 1998 Sep 14;805(1-2):207-12.

Chiba A, Akema T, Iigo M, Nagami Y, Kimura F, Toyoda J. 
A possible role of the pineal gland in acute immobilization-related suppression of naloxone-induced LH release in ovariectomized estrogen-primed rats. 
J Neuroendocrinol. 1998 Feb;10(2):79-84.

Akema T, Chiba A, Ikeda T, Nagami Y, Kimura F, Toyoda J. 
Melatonin inhibits naloxone-induced luteinizing hormone release in ovariectomized estrogen-primed rats. 
J Neuroendocrinol. 1997 Nov;9(11):849-57.

Mitsushima D, Jinnai K, Kimura F. 
Possible role of the gamma-aminobutyric acid-A receptor system in the timing of the proestrous luteinizing hormone 
surge in rats. 
Endocrinology. 1997 May;138(5):1944-8.

Mitsushima D, Kimura F. 
The maturation of GABA(A) receptor-mediated control of luteinizing hormone secretion in immature male rats. 
Brain Res. 1997 Feb 14;748(1-2):258-62.

Chiba A, Akema T, Nagami Y, Kimura F, Toyoda J. 
Differential inhibition of NMDA- and naloxone-induced LH release by NMDA receptor antagonist and CRH in ovariectomized estrogen-primed rats. 
Neuroendocrinology. 1997 Feb;65(2):141-6.

Funabashi T, Jinnai K, Kimura F. 
Bicuculline infusion advances the timing of Fos expression in LHRH neurons in the preoptic area of proestrous rats. 
Neuroreport. 1997 Feb 10;8(3):771-4.

Funabashi T, Jinnai K, Kimura F. 
Fos expression by naloxone in LHRH neurons of the mediobasal hypothalamus and effects of pentobarbital sodium in the proestrous rat. 
J Neuroendocrinol. 1997 Feb;9(2):87-92.

Hiruma H, Uemura T, Kimura F. 
Neuronal synchronization and ionic mechanisms for propagation of excitation in the functional network of immortalized GT1-7 neurons: optical imaging with a voltage-sensitive dye. 
J Neuroendocrinol. 1997 Nov;9(11):835-40.

Uemura T, Nishimura J, Yamaguchi H, Hiruma H, Kimura F, Minaguchi H. 
Effects of noradrenaline on GnRH-secreting immortalized hypothalamic (GT1-7) neurons. 
Endocr J. 1997 Feb;44(1):73-8.

Endo Y, Nishimura JI, Kobayashi S, Kimura F. 
Long-term glucocorticoid treatments decrease local cerebral blood flow in the rat hippocampus, in association with histological damage. 
Neuroscience. 1997 Aug;79(3):745-52.

Mizuno T, Kimura F. 
Attenuated stress response of hippocampal acetylcholine release and adrenocortical secretion in aged rats. 
Neurosci Lett. 1997 Jan 24;222(1):49-52.

Noguchi K, Arita J, Nagamoto A, Hosaka M, Kimura F. 
A quantitative analysis of testosterone action on FSH secretion from individual pituitary cells using the cell immunoblot assay. 
J Endocrinol. 1996 Mar;148(3):427-33.

Endo Y, Nishimura JI, Kimura F. 
Impairment of maze learning in rats following long-term glucocorticoid treatments. 
Neurosci Lett. 1996 Jan 26;203(3):199-202.

Mitsushima D, Mizuno T, Kimura F. 
Age-related changes in diurnal acetylcholine release in the prefrontal cortex of male rats as measured by microdialysis. 
Neuroscience. 1996 May;72(2):429-34.

Mizuno T, Kimura F. 
Medial septal injection of naloxone elevates acetylcholine release in the hippocampus and induces behavioral seizures in rats. 
Brain Res. 1996 Mar 25;713(1-2):1-7.

Akema T, Chiba A, Shinozaki R, Oshida M, Kimura F, Toyoda J. 
Acute immobilization stress and intraventricular injection of CRF suppress naloxone-induced LH release in ovariectomized estrogen-primed rats. 
J Neuroendocrinol. 1996 Aug;8(8):647-52. 

Akema T, Chiba A, Oshida M, Kimura F, Toyoda J. 
Permissive role of corticotropin-releasing factor in the acute stress-induced prolactin release in female rats. 
Neurosci Lett. 1995 Sep 29;198(2):146-8.

Akema T, Chiba A, Shinozaki R, Oshida M, Kimura F, Toyoda J. 
Acute stress suppresses the N-methyl-D-aspartate-induced luteinizing hormone release in the ovariectomized estrogen-primed rat. 
Neuroendocrinology. 1995 Sep;62(3):270-6.

Kimura F, Jinnai K, Sano A. 
LHRH pulse generator is stimulated by naloxone in the pentobarbital-blocked proestrous rat. 
J Neuroendocrinol. 1995 Dec;7(12):917-22.

Kimura F, Sano A. 
The effect of pentobarbital on the electrical activity of LHRH pulse generator in the ovariectomized rat with or without estrogen priming. 
J Neuroendocrinol. 1995 Dec;7(12):911-5.

Hiruma H, Kimura F. 
Luteinizing hormone-releasing hormone is a putative factor that causes LHRH neurons to fire synchronously in ovariectomized rats. 
Neuroendocrinology. 1995 May;61(5):509-16.

Funabashi T, Kimura F. 
The number of luteinizing hormone-releasing hormone immunoreactive neurons is significantly decreased in the forebrain of old-aged female rats. 
Neurosci Lett. 1995 Apr 14;189(2):85-8.

Kojima Y, Arita J, Kuwana N, Kimura F. 
Dopamine responsiveness of human prolactinoma cells as determined by the reverse hemolytic plaque assay. 
Endocr J. 1995 Jun;42(3):355-60.

Arita J, Kojima Y, Yamamoto I, Mazawa S, Kimura F. 
Somatotropes and thyrotropes in the rat anterior pituitary gland cosecrete substance P: analysis by the sandwich cell immunoblot assay. 
Neuroendocrinology. 1994 Dec;60(6):567-74.

Kato A, Hiruma H, Kimura F. 
Acute estradiol modulation of electrical activity of the LHRH pulse generator in the ovariectomized rat: restoration by naloxone. 
Neuroendocrinology. 1994 May;59(5):426-31.

Nishihara M, Sano A, Kimura F. 
Cessation of the electrical activity of gonadotropin-releasing hormone pulse generator during the steroid-induced surge of luteinizing hormone in the rat. 
Neuroendocrinology. 1994 Jun;59(6):513-9.

Endo Y, Nishimura J, Kimura F. 
Adrenalectomy increases local cerebral blood flow in the rat hippocampus. 
Pflugers Arch. 1994 Feb;426(3-4):183-8.

Hiruma H, Sano A, Kimura F. 
Injection of bicuculline elicits firing of luteinizing hormone releasing hormone pulse generator in muscimol-treated ovariectomized rats. 
Brain Res. 1994 Apr 4;641(2):191-7.

Funabashi T, Hashimoto R, Jinnai K, Kimura F. 
Microinjection of LHRH and its antagonistic analog into the medial preoptic area does not affect pulsatile secretion of LH in ovariectomized rats. 
Endocr J. 1994 Oct;41(5):559-63.

Endo Y, Mizuno T, Fujita K, Funabashi T, Kimura F. 
Soft-diet feeding during development enhances later learning abilities in female rats. 
Physiol Behav. 1994 Oct;56(4):629-33.

Mizuno T, Arita J, Kimura F. 
Spontaneous acetylcholine release in the hippocampus exhibits a diurnal variation in both young and old rats. 
Neurosci Lett. 1994 Sep 12;178(2):271-4.

Mizuno T, Ito E, Kimura F. 
Pentobarbital sodium inhibits the release of noradrenaline in the medial preoptic area in the rat. 
Neurosci Lett. 1994 Mar 28;170(1):111-3.

Funabashi T, Kimura F. 
Effects of estrogen and estrogen receptor messenger RNA levels in young and middle-aged female rats: comparison of medial preoptic area and mediobasal hypothalamus. 
Acta Biol Hung. 1994;45(2-4):223-31.

Kimura F, Jinnai K, Funabashi T. 
A GABAB-receptor mechanism is involved in the prolactin release in both male and female rats. 
Neurosci Lett. 1993 Jun 11;155(2):183-6.

Kimura F, Sano A, Hiruma H, Funabashi T. 
Effects of gamma-aminobutyric acid-A receptor antagonist, bicuculline, on the electrical activity of luteinizing hormone-releasing hormone pulse generator in the ovariectomized rat. 
Neuroendocrinology. 1993 Apr;57(4):605-14.

Arita J, Kojima Y, Kimura F. 
Measurement of the secretion of a small peptide at the single cell level by the cell immunoblot assay: thyroidectomy increases the number of substance P-secreting anterior pituitary cells. 
Endocrinology. 1993 Jun;132(6):2682-8.

Akema T, Kimura F. 
Differential effects of GABAA and GABAB receptor agonists on NMDA-induced and noradrenaline-induced 
luteinizing-hormone release in the ovariectomized estrogen-primed rat. 
Neuroendocrinology. 1993 Jan;57(1):28-33.

Tanaka J, Nomura M, Kariya K, Nishimura J, Kimura F. 
Median preoptic neurons projecting to the hypothalamic paraventricular nucleus are sensitive to blood pressure changes. 
Brain Res. 1993 Mar 12;605(2):338-41.

Tanaka J, Nishimura J, Kimura F, Nomura M. 
Noradrenergic excitatory inputs to median preoptic neurones in rats. 
Neuroreport. 1992 Oct;3(10):946-8.

Akema T, Kimura F. 
Modulation of pulsatile LH secretion by baclofen, a selective GABAB receptor agonist, in ovariectomized rats. 
Neuroendocrinology. 1992 Aug;56(2):141-7.

Arita J, Kojima Y, Kimura F. 
Lactotrophs secreting small amounts of prolactin reveal great responsiveness to thyrotropin-releasing hormone: analysis by the sequential cell immunoblot assay. 
Endocrinology. 1992 Jun;130(6):3167-74.

Hiruma H, Nishihara M, Kimura F. 
Hypothalamic electrical activity that relates to the pulsatile release of luteinizing hormone exhibits diurnal variation in ovariectomized rats. 
Brain Res. 1992 Jun 5;582(1):119-22.

Nishimura J, Endo Y, Kimura F. 
Increases in cerebral blood flow in rat hippocampus after medial septal injection of naloxone. 
Stroke. 1992 Sep;23(9):1325-9;

Mizuno T, Endo Y, Arita J, Kimura F. 
Acetylcholine release in the rat hippocampus as measured by the microdialysis method correlates with motor activity and exhibits a diurnal variation. 
Neuroscience. 1991;44(3):607-12.

Akema T, Kimura F. 
The mode of GABAB receptor-mediated inhibition of the preovulatory luteinizing hormone surge in female rats. 
Brain Res. 1991 Oct 18;562(1):169-72.

Akema T, Kimura F. 
2-Hydroxysaclofen, a potent GABAB receptor antagonist, stimulates luteinizing hormone secretion in female rats. 
Brain Res. 1991 Apr 12;546(1):143-5.

Arita J, Kojima Y, Kimura F. 
Identification by the sequential cell immunoblot assay of a subpopulation of rat dopamine-unresponsive lactotrophs. 
Endocrinology. 1991 Apr;128(4):1887-94.

Arita J, Hashimoto R, Kimura F. 
The activity of catecholamine synthesis in the hypothalamus of female normotensive Wistar Kyoto and spontaneously hypertensive rats. 
Brain Res. 1991 Mar 8;543(1):157-9.

Nishihara M, Hiruma H, Kimura F. 
Interactions between the noradrenergic and opioid peptidergic systems in controlling the electrical activity of luteinizing hormone-releasing hormone pulse generator in ovariectomized rats. 
Neuroendocrinology. 1991 Oct;54(4):321-6.

Hashimoto R, Sano A, Nishimura J, Funabashi T, Kimura F. 
Naloxone injected into the preoptic region has hypophysiotropic and seizurogenic actions in rats. 
Endocrinol Jpn. 1991 Jun;38(3):287-95.

Endo M, Arita J, Fujita K, Kimura F. 
Mechanism for the cardiovascular action of intracerebroventricularly administered vasoactive intestinal polypeptide in rats. 
Exp Clin Endocrinol. 1991 Mar;97(1):55-62.

Funabashi T, Hiruma H, Arita J, Kimura F. 
Intraventricular injection of vasoactive intestinal polypeptide facilitates the development of amygdaloid kindling. 
Brain Res. 1991 Feb 8;541(1):110-4.

Kimura F, Nishihara M, Hiruma H, Funabashi T. 
Naloxone increases the frequency of the electrical activity of luteinizing hormone-releasing hormone pulse generator in long-term ovariectomized rats. 
Neuroendocrinology. 1991 Jan;53(1):97-102.

Hashimoto R, Kimura F. 
Long-term depressor effects of catecholamine neuronal grafts in the third ventricle of the brain in normotensive rats. 
Experientia. 1991 Jun 15;47(6):619-22.

Hashimoto R, Kimura F. 
Effects of intraventricular injection of delta receptor antagonist ICI 154, 129 on the secretion of luteinizing hormone and prolactin in the proestrous rat. 
Endocrinol Jpn. 1991 Apr;38(2):213-8.