Hiroki Abe#, Susumu
Jitsuki#, Waki Nakajima#, Yumi
Murata#, Aoi Jitsuki-Takahashi, Yuki Katsuno, Hirobumi
Tada, Akane Sano, Kumiko Suyama, Nobuyuki Mochizuki, Takashi Komori,
Hitoshi Masuyama, Tomohiro Okuda, Yoshio Goshima, Noriyuki Higo,
Takuya Takahashi.
CRMP2-binding compound, edonerpic maleate,
accelerates motor function recovery from brain damage.
Science, 360: 50-57, 2018 (#equal contribution)
Hirobumi
Tada, Tomoyuki Miyazaki, Kiwamu Takemoto, Susumu jitsuki, Waki
Nakajima, Mayu Koide, Naoko Yamamoto, Akiko Taguchi, Honami Kawai,
Kasane Komiya, Kumiko Suyama, Hiroki Abe, Akane Sano and Takuya
Takahashi.
Social isolation suppresses actin dynamics and
synaptic plasticity through ADF/cofilin inactivation in the
developing rat barrel cortex.
Scientific Reports,
Article number: 8471 (2017) ,
doi:10.1038/s41598-017-08849-3
.
Kiwamu Takemoto*, Hiroko Iwanari, Hirobumi Tada, Kumiko Suyama, Akane Sano,
Takeharu Nagai, Takao Hamakubo, and Takuya Takahashi*
Optical inactivation of synaptic AMPA receptors erases
fear memory.
Nature Biotechnology, 35(1);38-47, 2017 (*co-corresponding author)
Hirobumi Tada, Tomoyuki Miyazaki, Kiwamu Takemoto, Kenkichi Takase, Susumu Jitsuki, Waki Nakajima, Mayu Koide, Naoko Yamamoto, Kasane Komiya, Kumiko Suyama, Akane Sano, Akiko Taguchi, and Takuya Takahashi.
Neonatal isolation augments
social dominance by altering actin dynamics in the medial prefrontal cortex.
PNAS,1606351113, 2016.10
Matsumoto T, Fujimori K, Andoh-Noda T, Ando T, Kuzumaki N, Toyoshima M,
Tada H, Imaizumi K, Ishikawa M, Yamaguchi R, Isoda M, Zhi Zhou, Sato S,
Kobayashi T,
Ohtaka M, Nishimura K, Kurosawa H, Yoshikawa T, Takahashi T, Nakanishi M,
Ohyama M, Hattori N, Akamatsu W, and Okano H.
Functional Neurons Generated from T Cell-Derived Induced Pluripotent
Stem Cells for Neurological Disease Modeling
Stem Cell Reports,doi:10.1016/j.stemcr.2016.01.010
Nakajima W, Jitsuki S, Sano A, Takahashi T.
Sustained Enhancement of Lateral Inhibitory Circuit Maintains Cross Modal Cortical Reorganization
PLoS One, 11(2):e0149068, 2016, Feb 10.
Jitsuki S, Nakajima W, Takemoto K, Sano A, Tada H, Takahashi-Jitsuki A,
Takahashi T.
Nogo Receptor Signaling Restricts Adult Neural Plasticity by Limiting Synaptic AMPA Receptor Delivery.
Cerebral Cortex, doi: 10.1093/cercor/bhv232, 2015
Tada H, Koide M, Ara W, Shibata Y, Funabashi T, Suyama K, Goto T, Takahashi T.
Estrous Cycle-Dependent Phasic Changes in the Stoichiometry of Hippocampal
Synaptic AMPA Receptors in Rats.
Plos One, ;10(6):e0131359. , 2015 Jun 29
Tada M, Uchida H, Maeda T, Konishi M, Umeda S, Terasawa Y,
Nakajima S, Mimura M, Miyazaki T, Takahashi T.
Fear
Conditioning Induced by Interpersonal Conflicts in Healthy
Individuals.
Plos One, Published: May 15, 2015. DOI:
10.1371/journal.pone.0125729
Uchimoto K, Miyazaki T, Kamiya Y, Mihara T,
Koyama Y, Taguri M, Inagawa G,
Takahashi T, Goto T.
Isoflurane impairs learning and hippocampal long-term
potentiation via the saturation of synaptic plasticity.
Anesthesiology, 121(2) : 302-10,
2014
Mitsushima D, Sano A, Takahashi T.
A cholinergic trigger
drives learning-induced plasticity at hippocampal synapses.
Nature
Communications, Vol 4, Article number 2760, 2013.
Tada H, Kuroki Y, Funabashi T,
Kamiya Y, Goto T, Suyama K, Sano A, Mitsushima D, Etgen AM, Takahashi
T
Phasic synaptic
incorporation of GluR2-lacking AMPA receptors at gonadotropin-releasing hormone
neurons is involved in the generation of the luteinizing hormone surge in female
rats.
Neuroscience. 248, 664-669, 2013.
Miyazaki T, Kunii S, Jitsuki S, Sano A, Kuroiwa Y,
Takahashi T.
Social isolation perturbs experience-driven
synaptic glutamate receptor subunit 4 delivery in the developing rat barrel
cortex.
Eur J Neurosci. 37(10):1602-9, 2013.
Miyazaki T,
Takase K, Nakajima W, Tada H, Ohya D, Sano A, Goto T, Hirase H,
Malinow R,
Takahashi T.
Disrupted cortical function underlies behavior
dysfunction due to social isolation.
J Clin Invest. 122(7),
2690-701,2012.
Miyazaki T,
Kunii M, Tada H, Sano A, Kuroiwa Y, Goto T, Malinow R, Takahashi
T.
Developmental AMPA receptor subunit specificity during
experience-driven synaptic plasticity in the rat barrel cortex.
Brain
Res. 1435, 1-7. 2012.
Takahahi
T
Serotonin as a mediator of cross-modal cortical reorganization.
Commun Integr Biol. 4(4), 45-461, 2011.
Mitsushima D,
Ishihara K, Sano A, Kessels HW, Takahashi T.
Contaxtual
learning requires synaptic AMPA receptor delivery in the
hippocampus.
Proc Natl Acad Sci USA, 108(30), 12503-12508,
2011.
Jitsuki S,
Takemoto K, Kawasaki T, Tada H, Takahashi A, Becamel C, Sano A, Yuzaki M, Zukin
RS, Ziff EB, Kessels HW, and Takahashi T.
Serotonin mediates
cross-modal reorganization of cortical circuits.
Neuron, 69,
780-792, 2011.
Tada H, Okano
HJ, Takagi H, Shibata S, Yao I, Matsumoto M, Saiga T, Nakayama KI, Kashima
H, Takahashi T, Setou M, Okano H
"Fbxo45, a novel ubiquitin
ligase, regulates synaptic activity."
J. Biol. Chem.,
285(6):3840-9, 2010.
Mitsushima D,
Takase K, Takahashi T, Kimura F.
Activational and
organizational effects of gonadal steroids on sex-specific acetylcholine release
in the dorsal hippocampus.
J
Neuroendocrinol, 21(4):400-405,2009.
Jitsuki S,
Kimura F, Funabashi T, Takahashi T, Mitsushima D.
Sex-specific
24-h profile of extracellular serotonin levels in the medial prefrontal cortex.
Brain Res, 1260: 30-37, 2009.
Murota Y,
Fujii M, Sugiyama Y, Funabashi T, Yagami T, Takahashi T,
Goshima, Y.
DOPA cyclohexyl ester, a DOPA antagonist, blocks the
depressor responses elicited by microinjections of nicotine into the nucleus
tractus solitarii of rats.
Neurosci Lett. 12;442(2):114-7,
2008.
Yamashita N,
Morita A, Uchida Y, Nakamura F, Usui H, OhshimaT, Taniguchi M, Honnorat J,
Thomasset N, Takei K, Takahashi T, Kolattukudy P, Goshima
Y.
Regulation of spine development by semaphorin3A through cyclin-dependent
kinase 5 phosphorylation of collapsin response mediator protein 1.
J.
Neurosci. 14;27(46):12546-54, 2007.
Yamashita N,
Uchida Y, Oshima T, Hirai S, Nakamura F, Taniguchi M, Mikoshiba K, Honnorat J,
Kolattukudy P, Thomasset N, Takei K, Takahashi T, Goshima
Y.
Collapsin response mediator protein1 mediates reelin signaling in
cortical neuronal migration.
J. Neurosci. 26; 13357-13362,
2006.
Takahashi T, Svoboda K, Malinow R.
Experience
strengthening transmission by driving AMPA receptors into
synapses.
Science 299; 1585-1588, 2003.
Takahashi T, Strittmatter S.M.
PlexinA1 auto-inhibition
by the Plexin sema domain.
Neuron 29; 429-439,
2001.
Tomoda A, Mori
K, Kimura M, Takahashi T, Kitamura T.
One-year prevalence and
incidence of depression among first-year university students in Japan: a
preliminary study. Psychiatry Clin.
Neurosci. 54; 583-588.
2000.
Goshima Y,
Hori H, Sasaki Y, Yang T, Kagoshima-Maezono M, Li C, Takenaka T
Nakamura F, Takahashi T, Strittmatter S.M, Misu Y, Kawakami T.
Growth cone
neuropilin-1 mediates collapsin-1/semaIII Fasciliataion of antero- and
retrograde axoplasmic transport.
J. Neurobiol. 39; 579-589,
1999.
Takahashi T, Fournier A, Nakamura F, Wang L.-H, Murakami Y,
Kalb R.G, Fujisawa H, Strittmatter S.M.
Plexin-1-neuropilin-1 complexes form
functional semaphoring-3A receptors.
Cell 99; 59-69,
1999.
Nakamura F,
Tanaka M, Takahashi T, Kalb R. G, Strittmatter
S.M.
Neuropilin-1 extracellular domains mediate semaphoring D/III-induced
growth cone collapse.
Neuron 21; 1093-1100,
1998.
Takahashi T, Nakamura F, Jin J, Kalb R.G, Strittmatter
S.M.
Semaphorin A and E act as antagonists of neuropilin-1 and agonists of
neuropilin-2 receptors.
Nature Neurosci. 1; 487-493,
1998.
Takahashi T, Nakamura F, Strittmatter S.M.
Neuronal and
non-neuronal collapsin-1 binding sites in developing chick are distinct from
other semaphoring binding sites.
J. Neurosci. 17; 9183-9193,
1997.
Okano H,
Yoshikawa S, Suzuki A, Ueno N, Kaizu M, Okabe M, Takahashi T,
Matsumoto M, Sawamoto K, Mikoshiba K.
Cloning of a Drosophila melanogaster
homologue of the mouse type-I bone morphogenetic proteins -2/-4 receptor: a
potential decapentaplegic receptor.
Gene 148; 203-209,
1994.
Matsuo K, Clay
O, Takahashi T, Silke J, Schaffner W.
Evidence for erosion Of
mouse CpG islands during mammalian evolution.
Som. Cell &Mol.
Genet.19; 543-555, 1993.
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