横浜市立大学大学院・医学研究科 生理学









教室員の紹介

美津島 大 (みつしま だい)

(医学部講義 )

生理学(神経、運動、筋肉、内分泌、生殖、消化器)  

(横浜市大の教員情報)

   https://ycursc.yokohama-cu.ac.jp/drams/search.do?type=v01&xid=50f013f45db95099

(主要論文・総説)

Mitsushima D, Sano A, Takahashi T.
A cholinergic trigger drives learning-induced plasticity at hippocampal synapses.
Nature Communications, Vol 4, Article number 2760, 2013.

Mitsushima D, Ishihara K, Sano A, Kessels HW, Takahashi T.
Contaxtual learning requires synaptic AMPA receptor delivery in the hippocampus.
Proc Natl Acad Sci USA, 108(30),12503-12508, 2011.

Mitsushima D.  
Sex differences in the cholinergic system in rats: behavioural consequences. In: Current Topics in Behavioral Neurosciences (CTBN) book series. Editor: Prof. Jo Neil. Springer, Heidelberg, Germany. Invited from editor, 8: 57-71, 2011.

Mitsushima D.
Sex Steroids and Acetylcholine Release in Hippocampus. In: Vitamins and Hormones - Hormones of the limbic system. Editor: Prof. Gerald Litwack. Academic Press /Elsevier, NY, USA. Invited from editor, 82:263-277, 2010.

Solinger JA, Paolinelli R, Kloss H, Scorza FB, Marchesi S, Sauder U, Mitsushima D, Capuani F, St?rzenbaum SR, Cassata G. The Caenorhabditis elegans Elongator complex regulates neuronal alpha-tubulin acetylation. PLoS Genet, 6: e1000820. Jan, 2010.

Takase K & Mitsushima D.
Sex difference in learning and memory: effects of sex differentiation, development, and environments on the basal forebrain cholinergic system. In: Horizons in Neuroscience Research, Volume 2. Editor: Dr. Andres Costa and Eugenio Villalba, Nova Science Publisher Inc, NY, USA. Invited from editor, 2010.

Tin-Tin-Win-Shwe & Mitsushima D.
Neural network controlling GnRH neurons in sexual dimorphism of gonadotropin release. In: Current Trends in Endocrinology. Editor: Prof. Ninu Joseph. Research Trends, Kerala. Invited from editor, 4:65-75, 2010.

Higashida T, Jitsuki S, Kubo A, Mitsushima D, Kamiya Y, Kanno H. Skin-derived precursors differentiate into dopaminergic neuronal cells in the brains of Parkinson's disease model rats. J Neurosurg, 113:648-655, 2010.

Furuta M, Mitsushima D, Shinohara K, Kimura F, Funabashi T. Food availability affects orexin A/ hypocretin-1-induced inhibition of pulsatile luteinizing hormone secretion in female rats. Neuroendocrinology, 91:41-47, 2010.

Hagiwara H, Kimura F, Mitsushima D, Funabashi T. Formalin-induced nociceptive behavior and c-Fos expression in middle-aged female rats. Physiol Behav, 100:101-104, 2010.

Mitsushima D, Takase K, Takahashi T, Kimura F.
Activational and organizational effects of gonadal steroids on sex-specific acetylcholine release in the dorsal hippocampus.
J Neuroendocrinol, review article, 21: 400-405, 2009.

Mitsushima D, Takase K, Funabashi T, Kimura F.
Gonadal steroids maintain 24-h acetylcholine release in the hippocampus: organizational and activational effects in behaving rats.
J Neurosci, 29: 3808-3815, 2009.

Funabashi T, Hagiwara H, Mogi K, Mitsushima D, Shinohara K, Kimura F. Sex differences in the responses of orexin neurons in the lateral hypothalamic area and feeding behavior to fasting. Neurosci Lett, 463:31-34, 2009.

Hagiwara H, Ishida M, Arita J, Mitsushima D, Takahashi T, Kimura F, Funabashi T. The cAMP response element-binding protein in the bed nucleus of the stria terminalis modulates the formalin-induced pain behavior in the female rat. Eur J Neurosci, 30:2379-2386, 2009.

Takase K, Kimura F, Yagami T, Mitsushima D*.
Sex-specific 24-h acetylcholine release profile in the medial prefrontal cortex: simultaneous measurement of spontaneous locomotor activity in behaving rats.
Neuroscience
, 159: 7-15, 2009.

Jitsuki S, Kimura F, Funabashi T, Takahashi T, Mitsushima D*.
Sex-specific 24-h profile of extracellular serotonin levels in the medial prefrontal cortex. Brain Res, 1260: 30-37, 2009.

Tin-Tin-Win-Shwe, Mitsushima D, Yamamoto S, Funabashi T, Fujimaki H.
Strain differences in extracellular amino acid neurotransmitter levels in the hippocampi of MHC-congenic mice in response to toluene exposure.
Neuroimmunomodulation, 16: 185-190, 2009.

Tin-Tin-Win-Shwe, Hojo R, Mitsushima D, Nakajima D, Yamamoto S, Fujimaki H. Establishment of a mouse model to assess brain neurotransmitter level and learning performance simultaneously following toxic chemical exposure: using in vivo microdialysis and schedule-controlled operant behavior.
J UOEH, 31: 1-11, 2009.

Tin-Tin-Win-Shwe, Mitsushima D, Yamamoto S, Fujitani Y, Funabashi T, Hirano S, Fujimaki H.
Extracellular glutamate level and NMDA receptor subunit expression in mouse olfactory bulb following nanoparticle-rich diesel exhaust exposure.
Inhalation Toxicology
, 21:828-836, 2009.

Mitsushima D, Takase K, Funabashi T, Kimura F.
Gonadal steroid hormones maintain the stress-induced acetylcholine release in the hippocampus: simultaneous measurements of the extracellular acetylcholine and serum corticosterone levels in the same subjects.
Endocrinology, 149: 802-811, 2008

Tin-Tin-Win-Shwe, Mitsushima D, Yamamoto S, Fukushima A, Funabashi T, Kobayashi T, Fujimaki H.
Changes in neurotransmitter levels and proinflammatory cytokine mRNA expressions in the mice olfactory bulb following nanoparticle exposure.
Toxicology and Applied Pharmacology, 226: 192-198, 2008. 

Takase K, Mitsushima D, Funabashi T, Kimura F.
Postpubertal feeding experience affects sex-specific spatial ability in rats. 
Physiol Behav, 93: 553-559, 2008.

Fukushima A, Funabashi T, Kawaguchi M, Mitsushima D, Kimura F.
Bisphenol A induces expression of transforming growth factor-b3 messenger ribonucleic acid in the medial preoptic area of adult ovariectomized rats as revealed by cDNA expression array. 
Neurosci Lett, 411: 81-85, 2007.

Hagiwara H, Funabashi T, Mitsushima D, Kimura F. Effects of neonatal testosterone treatment on sex differences in formalin-induced nociceptive behavior in rats. 
Neurosci Lett, 412: 264-267, 2007.

Tin-Tin-Win-Shwe, Mitsushima D, Nakajima D, Ahmed S, Yamamoto S, Tsukahara S, Kakeyama M, Goto S, Fujimaki H.
Toluene induces rapid and reversible rise of hippocampal glutamate and taurine neurotransmitter levels in mice. 
Toxicol Lett, 168:75-82, 2007.

Takase K, Mitsushima D, Funabashi T, Kimura F.
Sex difference in the 24-h acetylcholine release profile in the premotor/supplementary motor area of behaving rats. 
Brain Res, 1154:105-115, 2007.

Mitsushima D, Yamada K, Takase K, Funabashi T, Kimura F.
Sex differences in the basolateral amygdala: the extracellular levels of serotonin and dopamine, and their responses to restraint stress in rats. 
Eur J Neurosci, 24: 3245-3254, 2006.

Wang R, Hosaka M, Han L, Yokota-Hashimoto H, Suda M, Mitsushima D, Torii S, Takeuchi T.
Molecular probes for sensing the cholesterol composition of subcellular organelle membranes. 
Biochim Biophys Acta, 1761: 1169-1181, 2006.

Furuta M, Funabashi T, Kawaguchi M, Nakamura TJ, Mitsushima D, Kimura F.
Effects of p-nonylphenol and 4-tert-octylphenol on the anterior pituitary function in adult ovariectomized rats.
Neuroendocrinology, 84: 14-20, 2006.

Funabashi T, Sano A, Mitsushima D, Kimura F.
Nicotine inhibits pulsatile luteinizing hormone secretion in human males but not in human females, and tolerance to this nicotine effect is lost within one week of quitting smoking. 
J Clin Endocrinol Metabol, 90: 3908-3913, 2005.

Masuda J, Mitsushima D, Funabashi T, Kimura F. 
Sex and housing conditions affect the 24-h acetylcholine release profile in the hippocampus in rats. 
Neuroscience, 132: 537-542, 2005.

Mogi K, Funabashi T, Mitsushima D, Hagiwara H, Kimura F.
Sex difference in the response of melanin-concentrating hormone neurons in the lateral hypothalamic area to glucose, as revealed by the expression of phosphorylated cyclic adenosine 3 ユ,5 ユ-monophosphate response element-binding protein. 
Endocrinology, 146: 3325-3333, 2005.

Takase K, Funabashi T, Mogi K, Mitsushima D, Kimura F.
Feeding with powdered diet after weaning increases visuospatial ability in association with increases in the expression of N-methyl-D-aspartate receptors in the hippocampus of female rats. 
Neurosci Res, 53: 169-175, 2005.

Takase K, Mitsushima D, Masuda J, Mogi K, Funabashi T, Endo Y, Kimura F.
Feeding with powdered diet after weaning affects sex difference in acetylcholine release in the hippocampus in rats. 
Neuroscience, 136: 593-599, 2005.

Kimura F, Shinohara K, Funabashi T, Daikoku S, Suyama K, Mitsushima D, Sano A. 
Nicotine inhibition of pulsatile GnRH secretion is mediated by GABAA receptor system in the cultured rat embryonic olfactory placode. 
Psychoneuroendocrinology, 29: 749-756, 2004.

Masuda J, Mitsushima D, Kimura F.
Female rats living in small cages respond to restraint stress with both adrenocortical corticosterone release and acetylcholine release in the hippocampus. 
Neurosci Lett, 358: 169-172, 2004.

Tin-Tin-Win-Shwe, Mitsushima D, Shinohara K, Kimura F.
Sexual dimorphism of GABA release in the medial preoptic area and luteinizing hormone release in gonadectomized estrogen-primed rats. 
Neuroscience, 127: 243-250, 2004.

Funabashi T, Sano A, Mitsushima D, Kimura F.
Bisphenol a increases progesterone receptor immunoreactivity in the hypothalamus in a dose-dependent manner and affects sexual behaviour in adult ovariectomized rats.
J Neuroendocrinol, 15:134-40, 2003.

Mitsushima D, Funabashi T, Shinohara K, Kimura F.
Rats living in small cages respond to restraint stress with adrenocortical corticosterone release but not with hippocampal acetylcholine release. 
Psychoneuroendocrinology, 28: 574-583, 2003.

Mitsushima D, Tin-Tin-Win-Shwe, Kimura F. 
Sexual dimorphism in the GABAergic control of gonadotropin release in intact rats. Neurosci Res, review article, 46: 399-405, 2003.

Mitsushima D, Funabashi T, Kimura F.
Estrogen increases messenger RNA and immunoreactivity of aryl-hydrocarbon receptor nuclear translocator 2 in the rat mediobasal hypothalamus. 
Biochem Biophys Res Commun. 307: 248-253, 2003.

Mitsushima D, Masuda J, Kimura F.
Sex difference in the stress-induced release of acetylcholine in the hippocampus and corticosterone from the adrenalcortex in rats.
Neuroendocrinology, 78: 234-240, 2003.

Shinohara K, Funabashi T, Nakamura TJ, Mitsushima D, Kimura F. 
Differential regulation of pituitary adenyl cyclase activating peptide receptor variants in the rat suprachiasmatic nucleus. 
Neuroscience, 2002;110(2):301-8. 

Mitsushima D, Tin-Tin-Win-Shwe, Funabashi T, Shinohara K, Kimura F. 
GABA release in the medial preoptic area of cyclic female rats. 
Neuroscience, 2002 Aug 2;113(1):109-114. 

Tin-Tin-Win-Shwe, Mitsushima D, Kimura F. 
Profiles of in vivo GABA release in the medial preoptic area of intact and castrated male rats. 
Neuroendocrinology, 76: 290-296, 2002.

Funabashi T, Mitsushima D, Nakamura TJ, Uemura T, Hirahara F, Shinohara K, Suyama K, Kimura F.
Gonadotropin-releasing hormone (GnRH) surge generator in female rats.
Progress in Brain Res, 141:165-173., 2002.

Mitsushima D, Funabashi T, Shinohara K, Kimura F. 
Impairment of maze learning in rats by restricting environmental space. 
Neurosci Lett, 2001 Jan 12;297(2):73-76. 

Mitsushima D, He D, Funabashi T, Shinohara K, Kimura F. 
Increase in the number of detectable preoptic GAD67 immunoreactive cells in immature male rats. 
Neurosci Res, 2001 Jun;40(2):141-6. 

Nakamura TJ, Shinohara K, Funabashi T, Mitsushima D, Kimura F. 
Circadian and photic regulation of cryptochrome mRNAs in the rat pineal gland. 
Neurosci Res, 2001 Sep;41(1):25-32. 

He D, Mitsushima D, Uemura T, Hirahara F, Funabashi T, Shinohara K, Kimura F.
Effects of naloxone on the serum luteinizing hormone level and the number of Fos-positive gonadotropin-releasing hormone neurons in immature female rats. 
Brain Res, 2000 Mar 6;858(1):129-35. 

Saito K, Shinohara K, Morofushi M, Funabashi T, Mitsushima D, Hata M, Matsubara S, Kimura F.
Effects of irradiation on the sensitivity of melatonin release to norepinephrine in cultured pineal bodies of rats. 
Neurosci Lett, 2000 Apr 21;284(1-2):93-6. 

Funabashi T, Shinohara K, Mitsushima D, Kimura F.
Estrogen increases arginine-vasopressin V1a receptor mRNA in the preoptic area of young but not of middle-aged female rats. 
Neurosci Lett, 2000 May 19;285(3):205-8. 

Funabashi T, Shinohara K, Mitsushima D, Kimura F.
Gonadotropin-releasing hormone exhibits circadian rhythm in phase with arginine-vasopressin in co-cultures of the female rat preoptic area and suprachiasmatic nucleus. 
J Neuroendocrinol, 2000 Jun;12(6):521-8. 

Shinohara K, Morofushi M, Funabashi T, Mitsushima D, Kimura F.
Effects of 5alpha-androst-16-en-3alpha-ol on the pulsatile secretion of luteinizing hormone in human females. 
Chem Senses, 2000 Aug;25(4):465-7. 

Shinohara K, Funabashi T, Mitushima D, Kimura F.
Effects of gap junction blocker on vasopressin and vasoactive intestinal polypeptide rhythms in the rat suprachiasmatic nucleus in vitro. 
Neurosci Res, 2000 Sep;38(1):43-7. 

Shinohara K, Funabashi T, Mitushima D, Kimura F.
Effects of estrogen on the expression of connexin32 and connexin43 mRNAs in the suprachiasmatic nucleus of female rats. 
Neurosci Lett, 2000 Jun 2;286(2):107-10.

Keen KL, Burich AJ, Mitsushima D, Kasuya E, Terasawa E. 
Effects of pulsatile infusion of the GABA(A) receptor blocker bicuculline on the onset of puberty in female rhesus monkeys. 
Endocrinology, 1999 Nov;140(11):5257-66. 

Mitsushima D, Funabashi T, Kimura F. 
Fos expression in gonadotropin-releasing hormone neurons by naloxone or bicuculline in intact male rats. 
Brain Res, 1999 Aug 21;839(1):209-12. 

Hla-Hla-Aye, Jinnai K, Sano A, Funabashi T, Mitsushima D, Kimura F. 
Nicotine given intracerebroventricularly does not inhibit the preovulatory surge of LH and PRL secretion in female rats. 
Endocr J, 1998 Aug;45(4):575-80. 

Mitsushima D, Yamanoi C, Kimura F. 
Restriction of environmental space attenuates locomotor activity and hippocampal acetylcholine release in male rats. 
Brain Res, 1998 Sep 14;805(1-2):207-12. 

Mitsushima D, Jinnai K, Kimura F. 
Possible role of the gamma-aminobutyric acid-A receptor system in the timing of the proestrous luteinizing hormone surge in rats. 
Endocrinology, 1997 May;138(5):1944-8. 

Mitsushima D, Kimura F. 
The maturation of GABA(A) receptor-mediated control of luteinizing hormone secretion in immature male rats. 
Brain Res, 1997 Feb 14;748(1-2):258-62. 

Mitsushima D, Mizuno T, Kimura F. 
Age-related changes in diurnal acetylcholine release in the prefrontal cortex of male rats as measured by microdialysis. 
Neuroscience, 1996 May;72(2):429-34. 

Mitsushima D, Marzban F, Luchansky LL, Burich AJ, Keen KL, Durning M, Golos TG, Terasawa E. Role of glutamic acid decarboxylase in the prepubertal inhibition of the luteinizing hormone releasing hormone release in female rhesus monkeys. 
J Neurosci, 1996 Apr 15;16(8):2563-73. 

Mitsushima D, Yokawa T, Nishihara M, Takahashi M. 
Attenuation of the expression of circadian rhythms by chronic outputs from the VMH in rats. 
Physiol Behav, 1994 Nov;56(5):891-9. 

Mitsushima D, Hei DL, Terasawa E. 
gamma-Aminobutyric acid is an inhibitory neurotransmitter restricting the release of luteinizing hormone-releasing hormone before the onset of puberty. 
Proc Natl Acad Sci U S A, 1994 Jan 4;91(1):395-9. 

Gore AC, Mitsushima D, Terasawa E. 
A possible role of neuropeptide Y in the control of the onset of puberty in female rhesus monkeys. 
Neuroendocrinology, 1993 Jul;58(1):23-34. 

Yokawa T, Mitsushima D, Itoh C, Konishi H, Shiota K, Takahashi M. 
The ventromedial nucleus of the hypothalamus outputs long-lasting running in rats.
Physiol Behav, 1989 Oct;46(4):713-7.