横浜市立大学大学院・医学研究科 生理学














教室員の紹介

舩橋 利也 (ふなばし としや)

(現 聖マリアンナ医科大学 生理学 教授)

(主な業績)

Tada H, Koide M, Ara W, Shibata Y, Funabashi T, Suyama K, Goto T, Takahashi T.
Estrous Cycle-Dependent Phasic Changes in the Stoichiometry of Hippocampal Synaptic AMPA Receptors in Rats.
Plos One,
;10(6):e0131359. , 2015 Jun 29

Mitsushima D, Takase K, Funabashi T, Kimura F.
Gonadal steroids maintain 24-h acetylcholine release in the hippocampus: organizational and activational effects in behaving rats.
J Neurosci, 29: 3808-3815, 2009.

Tin-Tin-Win-Shwe, Mitsushima D, Yamamoto S, Funabashi T, Fujimaki H. Strain differences in extracellular amino acid neurotransmitter levels in the hippocampi of MHC-congenic mice in response to toluene exposure.
Neuroimmunomodulation, 16: 185-190, 2009.

Jitsuki S, Kimura F, Funabashi T, Takahashi T, Mitsushima D.
Sex-specific 24-h profile of extracellular serotonin levels in the medial prefrontal cortex.
Brain Res, 1260: 30-37, 2009.

Mitsushima D, Takase K, Funabashi T, Kimura F. 
Gonadal steroid hormones maintain the stress-induced acetylcholine release in the hippocampus: simultaneous measurements of the extracellular acetylcholine and serum corticosterone levels in the same subjects. 
Endocrinology,149: 802-811, 2008.

Tin-Tin-Win-Shwe, Mitsushima D, Yamamoto S, Fukushima A, Funabashi T, Kobayashi T, Fujimaki H. 
Changes in neurotransmitter levels and proinflammatory cytokine mRNA expressions in the mice olfactory bulb following nanoparticle exposure.
Toxicology and Applied Pharmacology, 226: 192-198, 2008. 

Takase K, Mitsushima D, Funabashi T, Kimura F. 
Sex difference in the 24-h acetylcholine release profile in the premotor/supplementary motor area of behaving rats. 
Brain Res, 1154: 105-115, 2007.

Takase K, Mitsushima D, Funabashi T, Kimura F. 
Postpubertal feeding experience affects sex-specific spatial abililty in rats. 
Physiol Behav, 93: 553-559, 2007.

Fukushima A, Funabashi T, Kawaguchi M, Mitsushima D, Kimura F. 
Bisphenol A induces transforming growth factor-bata3 mRNA in the preoptic area: a cDNA expression array and northern blot study. 
Neurosci Lett, 411: 81-85, 2007.

Hagiwara H, Funabashi T, Mitsushima D, Kimura F. 
Effects of neonatal testosterone treatment on sex differences in formalin-induced nociceptive behavior in rats. 
Neurosci Lett, 412: 264-267, 2007.

Ohtaki K, Aihara M, Takahashi H, Fujita H, Takahashi K, Funabashi T, Hirasawa T, Ikezawa Z.
Effects of tributyltin on the emotional behavior of C57BL/6 mice and the development of atopic dermatitis-like lesions in DS-Nh mice.
J Dermatol Sci, 47:209-216, 2007.

Fukushima A, Funabashi T, Kawaguchi M, Mitsushima D, Kimura F. 
Bisphenol A induces expression of transforming growth factor-b3 messenger ribonucleic acid in the medial preoptic area of adult ovariectomized rats as revealed by cDNA expression array. 
Neurosci Lett, 411: 81-85, 2006.

Furuta M, Funabashi T, Kawaguchi M, Nakamura TJ, Mitsushima D, Kimura F. 
Effects of p-Nonylphenol and 4-tert- Octylphenol on the Anterior Pituitary Functions in Adult Ovariectomized rats. 
Neuroendocrinology, 84: 14-20, 2006.

Hagiwara H, Funabashi T, Mitsushima D, Kimura F. 
Effects of neonatal testosterone treatment on sex differences in formalin-induced nociceptive behavior in rats. 
Neuroscience Letters, 412: 264-267, 2006.

Mitsushima D, Yamada K, Takase K, Funabashi T, Kimura F. 
Sex differences in the basolateral amygdala: the extracellular levels of serotonin and dopamine, and their responses to restraint stress in rats. 
Eur J Neurosci, 24: 3245-3254, 2006. (RI)

Murase, M., Uemura, T., Gao, M., Inada, M., Funabashi, T., Hirahara, F. 
GnRH antagonist-induced down-regulation of the mRNA expression of pituitary receptors: comparisons with GnRH agonist effects. 
Endocrine Journal 52: 131-137, 2005.

Funabashi, T., Sano, A., Mitsushima, D., Kimura, F. 
Nicotine inhibits pulsatile luteinizing hormone secretion in human males but not in human females, and tolerance to this nicotine effect is lost within one week of quitting smoking. 
The Journal of Clinical Endocrinology & Metabolism 90: 3908-3913, 2005.

Masuda, J., Mitsushima, D., Funabashi, T., Kimura, F. 
Sex and housing conditions affect the 24-h acetylcholine release profile in the hippocampus in rats. 
Neuroscience 132: 537-542, 2005.

Mogi, K., Funabashi, T., Mitsushima, D., Hagiwara, H., Kimura, F. 
Sex difference in the response of melanin-concentrating hormone neurons in the lateral hypothalamic area to glucose, as revealed by the expression of phosphorylated cyclic adenosine 3 ユ,5 ユ-monophosphate response element-binding protein. 
Endocrinology 146: 3325-3333, 2005.

Takase, K., Funabashi, T., Mogi, K., Mitsushima, D., Kimura, F. 
Feeding with powdered diet after weaning increases visuospatial ability in association with increases in the expression of N-methyl-D-aspartate receptors in the hippocampus of female rats. 
Neuroscience Research 53: 169-175, 2005.

Takase, K., Mitsushima, D., Masuda, J., Mogi, K., Funabashi, T., Endo, Y., Kimura, F. 
Feeding with powdered diet after weaning affects sex difference in acetylcholine release in the hippocampus in rats. 
Neuroscience 136: 593-599, 2005.

Quan, H., Funabashi, T., Kimura, F. 
Intracerebroventricular injection of corticotropin-releasing hormone receptor antagonist blocks the suppression of pulsatile luteinizing hormone secretion induced by neuromedin U in ovariectomized rats after 48 hours of fasting. 
Neuroscience Letters 369: 33-38, 2004.

Yang, X.J., Funabashi, T., Kow, L.M., Mobbs, C.V. 
A glucokinase/AP-1 glucose transduction mechanism in the ventromedial hypothalamic satiety center. 
Frontiers in Diabetes 16: 313-326, 2004.

Mizuno, T.M., Funabashi, T., Kleopoulos, S.P., Mobbs, C.V. 
Specific preservation of biosynthetic responses to insulin in adipose tissue may contribute to hyperleptinemia in insulin-resistant obese mice. 
The Journal of Nutrition 134: 1045-1050, 2004.

Suyama, K., Daikoku, S., Funabashi, T., Kimura, F. 
Effects of GABA and bicuculline on the electrical activity of rat olfactory placode neurons derived at E13.5 and cultured for 1 week on multi-electrode dishes. 
Endocrine Journal 51: 171-176, 2004.

Funabashi, T., Kawaguchi, M., Furuta, M., Fukushima, A., 
Kimura, F. 
Exposure to bisphenol A during gestation and lactation causes loss of sex difference in corticotropin-releasing hormone-immunoreactive neurons in the bed nucleus of the stria terminalis of rats. 
Psychoneuroendocrinology 29: 475-485, 2004.

Funabashi, T., Nakamura, T.J., Kimura, F. 
p-Nonylphenol, 4-tert-octylphenol and bisphenol A increase the expression of progesterone receptor mRNA in the frontal cortex of adult ovariectomized rats. 
Journal of Neuroendocrinology 16: 99-104, 2004.

Kimura, F., Shinohara, K., Funabashi, T., Daikoku, S., Suyama, K., Mitsushima, D., Sano, A. 
Nicotine inhibition of pulsatile GnRH secretion is mediated by GABAA receptor system in the cultured rat embryonic olfactory placode. 
Psychoneuroendocrinology 29: 749-756, 2004.

Masuda, J., Mitsushima, D., Kimura, F. 
Female rats living in small cages respond to restraint stress with both adrenocortical corticosterone release and acetylcholine release in the hippocampus. 
Neuroscience Letters 358: 169-172, 2004.

Mitsushima, D., Funabashi, T., Kimura, F. 
Estrogen increases messenger RNA and immunoreactivity of aryl-hydrocarbon receptor nuclear translocator 2 in the rat mediobasal hypothalamus. 
Biochemical and Biophysical Research Communications 307: 248-253, 2003.

Mitsushima, D., Funabashi, T., Shinohara, K., Kimura, F. 
Rats living in small cages respond to restraint stress with adrenocortical corticosterone release but not with hippocampal acetylcholine release. 
Psychoneuroendocrinology 28: 574-583, 2003.

Funabashi, T., Sano, A., Mitsushima, D., Kimura, F. 
Bisphenol A increases progesterone receptor immunoreactivity in the hypothalamus in a dose-dependent manner and affects sexual behaviour in adult ovariectomized rats. 
Journal of Neuroendocrinology 15: 134-140, 2003.

Mitsushima D, Funabashi T, Shinohara K, Kimura F. 
Rats living in small cages respond to restraint stress with adrenocortical corticosterone release but not with hippocampal acetylcholine release. 
Psychoneuroendocrinology  28: 574-583, 2003.

Funabashi T, Sano A, Mitsushima D, Kimura F. 
Bisphenol A increases progesterone receptor immunoreactive cells in the hypothalamus in a dose-dependent manner and affects sexual behavior in adult ovariectomized rats. 
J Neuroendocrinology 15: 134-140, 2003.

Mitsushima D, Tin-Tin-Win-Shwe, Funabashi T, Shinohara K, Kimura F. 
GABA release in the medial preoptic area of cyclic female rats. 
Neuroscience 2002 Aug 2;113(1):109-114. 
PMID: 12123689

Shinohara K, Funabashi T, Nakamura TJ, Mitsushima D, Kimura F. 
Differential regulation of pituitary adenyl cyclase activating peptide receptor variants in the rat suprachiasmatic nucleus. 
Neuroscience 2002;110(2):301-8. 
PMID: 11958871

Furuta M, Funabashi T, Kimura F. 
Suppressive Action of Orexin A on Pulsatile Luteinizing Hormone Secretion Is Potentiated by a Low Dose of Estrogen in Ovariectomized Rats. 
Neuroendocrinology. 2002 Mar;75(3):151-157.

Furuta M, Funabashi T, Kimura F. 
Intracerebroventricular administration of ghrelin rapidly suppresses pulsatile luteinizing hormone secretion in ovariectomized rats. 
Biochem Biophys Res Commun. 2001 Nov 9;288(4):780-5.

Nakamura TJ, Shinohara K, Funabashi T, Kimura F. 
Effect of estrogen on the expression of Cry1 and Cry2 mRNAs in the suprachiasmatic nucleus of female rats. 
Neurosci Res. 2001 Nov;41(3):251-5.

Mitsushima D, He D, Funabashi T, Shinohara K, Kimura F. 
Increase in the number of detectable preoptic GAD67 immunoreactive cells in immature male rats. 
Neurosci Res. 2001 May 40(2):141-146.

Mitsushima D, Funabashi T, Shinohara K, Kimura F. 
Impairment of maze learning in rats by restricting environmental space. 
Neurosci Lett. 2001 Jan 12;297(2):73-6.

Funabashi T, Suyama K, Uemura T, Hirose M, Hirahara F, Kimura F. 
Immortalized Gonadotropin-Releasing Hormone Neurons (GT1-7 Cells) Exhibit Synchronous Bursts of Action Potentials. 
Neuroendocrinology. 2001 Mar;73(3):157-165.

Shinohara K, Morofushi M, Funabashi T, Kimura F. 
Axillary pheromones modulate pulsatile LH secretion in humans. 
Neuroreport. 2001 Apr 17;12(5):893-5.

Funabashi T, Kleopoulos SP, Brooks PJ, Kimura F, Pfaff DW, Shinohara K, Mobbs CV. 
Changes in estrogenic regulation of estrogen receptor alpha mRNA and progesterone receptor mRNA in the female rat hypothalamus during aging: an in situ hybridization study. 
Neurosci Res. 2000 Sep;38(1):85-92.

Shinohara K, Funabashi T, Mitushima D, Kimura F. 
Effects of gap junction blocker on vasopressin and vasoactive intestinal polypeptide rhythms in the rat suprachiasmatic nucleus in vitro. 
Neurosci Res. 2000 Sep;38(1):43-7.

Shinohara K, Morofushi M, Funabashi T, Mitsushima D, Kimura F. 
Effects of 5alpha-androst-16-en-3alpha-ol on the pulsatile secretion of luteinizing hormone in human females. 
Chem Senses. 2000 Aug;25(4):465-7.

Morofushi M, Shinohara K, Funabashi T, Kimura F. 
Positive relationship between menstrual synchrony and ability to smell 5alpha-androst-16-en-3alpha-ol. 
Chem Senses. 2000 Aug;25(4):407-11.

Funabashi T, Shinohara K, Mitsushima D, Kimura F. 
Gonadotropin-releasing hormone exhibits circadian rhythm in phase with arginine-vasopressin in co-cultures of the female rat preoptic area and suprachiasmatic nucleus. 
J Neuroendocrinol. 2000 Jun;12(6):521-8.

Shinohara K, Funabashi T, Mitushima D, Kimura F. 
Effects of estrogen on the expression of connexin32 and connexin43 mRNAs in the suprachiasmatic nucleus of female rats. 
Neurosci Lett. 2000 Jun 2;286(2):107-10.

Funabashi T, Shinohara K, Mitsushima D, Kimura F. 
Estrogen increases arginine-vasopressin V1a receptor mRNA in the preoptic area of young but not of middle-aged female rats. 
Neurosci Lett. 2000 May 19;285(3):205-8.

Saito K, Shinohara K, Morofushi M, Funabashi T, Mitsushima D, Hata M, Matsubara S, Kimura F. 
Effects of irradiation on the sensitivity of melatonin release to norepinephrine in cultured pineal bodies of rats. 
Neurosci Lett. 2000 Apr 21;284(1-2):93-6.

Funabashi T, Jinnai K, Sano A, Shinohara K, Kimura F. 
Pentobarbital stimulates the activity of the GnRH pulse generator interacting with opioid neurons in rats in proestrus. 
Psychoneuroendocrinology. 2000 Apr;25(3):277-87.

Shinohara K, Hiruma H, Funabashi T, Kimura F. 
GABAergic modulation of gap junction communication in slice cultures of the rat suprachiasmatic nucleus. 
Neuroscience. 2000;96(3):591-6.

Shinohara K, Uchiyama M, Okawa M, Saito K, Kawaguchi M, Funabashi T, Kimura F. 
Menstrual changes in sleep, rectal temperature and melatonin rhythms in a subject with premenstrual syndrome. 
Neurosci Lett. 2000 Mar 10;281(2-3):159-62.

He D, Mitsushima D, Uemura T, Hirahara F, Funabashi T, Shinohara K, Kimura F. 
Effects of naloxone on the serum luteinizing hormone level and the number of Fos-positive gonadotropin-releasing hormone neurons in immature female rats. 
Brain Res. 2000 Mar 6;858(1):129-35.

Funabashi T, Daikoku S, Shinohara K, Kimura F. 
Pulsatile gonadotropin-releasing hormone (GnRH) secretion is an inherent function of GnRH neurons, as revealed by the culture of medial olfactory placode obtained from embryonic rats. 
Neuroendocrinology. 2000 Feb;71(2):138-44.

Mitsushima D, Funabashi T, Kimura F. 
Fos expression in gonadotropin-releasing hormone neurons by naloxone or bicuculline in intact male rats. 
Brain Res. 1999 Aug 21;839(1):209-12.

Sano A, Funabashi T, Kawaguchi M, Shinohara K, Kimura F. 
Intravenous injections of nicotine decrease the pulsatile secretion of LH by inhibiting the gonadotropin-releasing hormone (GnRH) pulse generator activity in female rats. 
Psychoneuroendocrinology. 1999 May;24(4):397-407.

Funabashi T, Aiba S, Sano A, Shinohara K, Kimura F. 
Intracerebroventricular injection of arginine-vasopressin V1 receptor antagonist attenuates the surge of luteinizing hormone and prolactin secretion in proestrous rats. 
Neurosci Lett. 1999 Jan 22;260(1):37-40.

He D, Funabashi T, Sano A, Uemura T, Minaguchi H, Kimura F. 
Effects of glucose and related substrates on the recovery of the electrical activity of gonadotropin-releasing hormone pulse generator which is decreased by insulin-induced hypoglycemia in the estrogen-primed ovariectomized rat. 
Brain Res. 1999 Feb 27;820(1-2):71-6.

Hla-Hla-Aye, Jinnai K, Sano A, Funabashi T, Mitsushima D, Kimura F. 
Nicotine given intracerebroventricularly does not inhibit the preovulatory surge of LH and PRL secretion in female rats. 
Endocr J. 1998 Aug;45(4):575-80.

Shinohara K, Funabashi T, Kimura F. 
Temporal profiles of vasoactive intestinal polypeptide precursor mRNA and its receptor mRNA in the rat suprachiasmatic nucleus. 
Brain Res Mol Brain Res. 1999 Jan 8;63(2):262-7.

Kawaguchi M, Funabashi T, Kimura F. 
Insulin-induced hypoglycemia does not impair the surge of luteinizing hormone secretion in the proestrous rat. 
Neurosci Lett. 1998 Nov 13;256(3):131-4.

Funabashi T, Kleopoulos SP, Kimura F, Mobbs CV. 
Changes in neurotensin mRNA by estrogen in the female rat preoptic area during aging: an in situ hybridization histochemistry study.
Gen Comp Endocrinol. 1998 Dec;112(3):364-71.

Funabashi T, Jinnai K, Kimura F. 
Bicuculline infusion advances the timing of Fos expression in LHRH neurons in the preoptic area of proestrous rats. 
Neuroreport. 1997 Feb 10;8(3):771-4.

Funabashi T, Jinnai K, Kimura F. 
Fos expression by naloxone in LHRH neurons of the mediobasal hypothalamus and effects of pentobarbital sodium in the proestrous rat. 
J Neuroendocrinol. 1997 Feb;9(2):87-92.

Funabashi T, Kimura F. 
The number of luteinizing hormone-releasing hormone immunoreactive neurons is significantly decreased in the forebrain of old-aged female rats. 
Neurosci Lett. 1995 Apr 14;189(2):85-8.

Funabashi T, Hashimoto R, Jinnai K, Kimura F. 
Microinjection of LHRH and its antagonistic analog into the medial preoptic area does not affect pulsatile secretion of LH in ovariectomized rats. 
Endocr J. 1994 Oct;41(5):559-63.

Endo Y, Mizuno T, Fujita K, Funabashi T, Kimura F. 
Soft-diet feeding during development enhances later learning abilities in female rats. 
Physiol Behav. 1994 Oct;56(4):629-33.

Funabashi T, Kimura F. 
Effects of estrogen and estrogen receptor messenger RNA levels in young and middle-aged female rats: comparison of medial preoptic area and mediobasal hypothalamus. 
Acta Biol Hung. 1994;45(2-4):223-31.

Kimura F, Jinnai K, Funabashi T. 
A GABAB-receptor mechanism is involved in the prolactin release in both male and female rats. 
Neurosci Lett. 1993 Jun 11;155(2):183-6.

Kimura F, Sano A, Hiruma H, Funabashi T. 
Effects of gamma-aminobutyric acid-A receptor antagonist, bicuculline, on the electrical activity of luteinizing hormone-releasing hormone pulse generator in the ovariectomized rat. 
Neuroendocrinology. 1993 Apr;57(4):605-14.

Hashimoto R, Sano A, Nishimura J, Funabashi T, Kimura F. 
Naloxone injected into the preoptic region has hypophysiotropic and seizurogenic actions in rats. 
Endocrinol Jpn. 1991 Jun;38(3):287-95.

Funabashi T, Hiruma H, Arita J, Kimura F. 
Intraventricular injection of vasoactive intestinal polypeptide facilitates the development of amygdaloid kindling. 
Brain Res. 1991 Feb 8;541(1):110-4.

Kimura F, Nishihara M, Hiruma H, Funabashi T. 
Naloxone increases the frequency of the electrical activity of luteinizing hormone-releasing hormone pulse generator in long-term ovariectomized rats. 
Neuroendocrinology. 1991 Jan;53(1):97-102.