舩橋 利也 (ふなばし としや)
(現 聖マリアンナ医科大学 生理学 教授)
(主な業績)
Tada H, Koide M, Ara W, Shibata Y, Funabashi T, Suyama K, Goto T, Takahashi T.
Estrous Cycle-Dependent Phasic Changes in the Stoichiometry of Hippocampal
Synaptic AMPA Receptors in Rats.
Plos One, ;10(6):e0131359. , 2015 Jun 29
Mitsushima D, Takase K, Funabashi T,
Kimura F. Gonadal steroids maintain 24-h acetylcholine
release in the hippocampus: organizational and activational
effects in behaving rats. J Neurosci, 29:
3808-3815, 2009.
Tin-Tin-Win-Shwe, Mitsushima D, Yamamoto
S, Funabashi T, Fujimaki H. Strain differences in extracellular
amino acid neurotransmitter levels in the hippocampi
of MHC-congenic mice in response to toluene exposure.
Neuroimmunomodulation, 16: 185-190, 2009.
Jitsuki S, Kimura F, Funabashi T, Takahashi
T, Mitsushima D. Sex-specific 24-h profile of extracellular
serotonin levels in the medial prefrontal cortex.
Brain Res, 1260: 30-37, 2009.
Mitsushima D, Takase K, Funabashi T,
Kimura F. Gonadal steroid hormones maintain the
stress-induced acetylcholine release in the hippocampus:
simultaneous measurements of the extracellular acetylcholine
and serum corticosterone levels in the same subjects.
Endocrinology,149:
802-811, 2008.
Tin-Tin-Win-Shwe, Mitsushima D, Yamamoto
S, Fukushima A, Funabashi T, Kobayashi T, Fujimaki H.
Changes in neurotransmitter
levels and proinflammatory cytokine mRNA expressions
in the mice olfactory bulb following nanoparticle exposure.
Toxicology and Applied Pharmacology,
226: 192-198, 2008.
Takase K, Mitsushima D, Funabashi T,
Kimura F. Sex difference in the 24-h acetylcholine
release profile in the premotor/supplementary motor
area of behaving rats. Brain Res, 1154:
105-115, 2007.
Takase K, Mitsushima D, Funabashi T,
Kimura F. Postpubertal feeding experience affects
sex-specific spatial abililty in rats. Physiol
Behav, 93: 553-559, 2007.
Fukushima A, Funabashi T, Kawaguchi
M, Mitsushima D, Kimura F. Bisphenol A induces
transforming growth factor-bata3 mRNA in the preoptic
area: a cDNA expression array and northern blot study.
Neurosci Lett, 411: 81-85, 2007.
Hagiwara H, Funabashi T, Mitsushima
D, Kimura F. Effects of neonatal testosterone
treatment on sex differences in formalin-induced nociceptive
behavior in rats. Neurosci Lett, 412: 264-267,
2007.
Ohtaki K, Aihara M, Takahashi H, Fujita
H, Takahashi K, Funabashi T, Hirasawa T, Ikezawa Z.
Effects of tributyltin on the emotional behavior of
C57BL/6 mice and the development of atopic dermatitis-like
lesions in DS-Nh mice. J Dermatol Sci, 47:209-216,
2007.
Fukushima A, Funabashi T, Kawaguchi
M, Mitsushima D, Kimura F. Bisphenol A induces
expression of transforming growth factor-b3 messenger
ribonucleic acid in the medial preoptic area of adult
ovariectomized rats as revealed by cDNA expression array.
Neurosci Lett, 411: 81-85, 2006.
Furuta M, Funabashi T, Kawaguchi M,
Nakamura TJ, Mitsushima D, Kimura F. Effects of
p-Nonylphenol and 4-tert- Octylphenol on the Anterior
Pituitary Functions in Adult Ovariectomized rats.
Neuroendocrinology, 84: 14-20, 2006.
Hagiwara H, Funabashi T, Mitsushima
D, Kimura F. Effects of neonatal testosterone
treatment on sex differences in formalin-induced nociceptive
behavior in rats. Neuroscience Letters, 412:
264-267, 2006.
Mitsushima D, Yamada K, Takase K, Funabashi
T, Kimura F. Sex differences in the basolateral
amygdala: the extracellular levels of serotonin and
dopamine, and their responses to restraint stress in
rats. Eur J Neurosci, 24: 3245-3254, 2006.
(RI)
Murase, M., Uemura, T., Gao, M., Inada,
M., Funabashi, T., Hirahara, F. GnRH antagonist-induced
down-regulation of the mRNA expression of pituitary
receptors: comparisons with GnRH agonist effects.
Endocrine Journal 52: 131-137, 2005.
Funabashi, T., Sano, A., Mitsushima,
D., Kimura, F. Nicotine inhibits pulsatile luteinizing
hormone secretion in human males but not in human females,
and tolerance to this nicotine effect is lost within
one week of quitting smoking. The Journal of
Clinical Endocrinology & Metabolism 90: 3908-3913,
2005.
Masuda, J., Mitsushima, D., Funabashi,
T., Kimura, F. Sex and housing conditions affect
the 24-h acetylcholine release profile in the hippocampus
in rats. Neuroscience 132: 537-542, 2005.
Mogi, K., Funabashi, T., Mitsushima,
D., Hagiwara, H., Kimura, F. Sex difference in
the response of melanin-concentrating hormone neurons
in the lateral hypothalamic area to glucose, as revealed
by the expression of phosphorylated cyclic adenosine
3 ユ,5 ユ-monophosphate response element-binding protein.
Endocrinology 146: 3325-3333, 2005.
Takase, K., Funabashi, T., Mogi, K.,
Mitsushima, D., Kimura, F. Feeding with powdered
diet after weaning increases visuospatial ability in
association with increases in the expression of N-methyl-D-aspartate
receptors in the hippocampus of female rats. Neuroscience
Research 53: 169-175, 2005.
Takase, K., Mitsushima, D., Masuda,
J., Mogi, K., Funabashi, T., Endo, Y., Kimura, F.
Feeding with powdered diet after weaning affects sex
difference in acetylcholine release in the hippocampus
in rats. Neuroscience 136: 593-599, 2005.
Quan, H., Funabashi, T., Kimura, F.
Intracerebroventricular injection of corticotropin-releasing
hormone receptor antagonist blocks the suppression of
pulsatile luteinizing hormone secretion induced by neuromedin
U in ovariectomized rats after 48 hours of fasting.
Neuroscience Letters 369: 33-38, 2004.
Yang, X.J., Funabashi, T., Kow, L.M.,
Mobbs, C.V. A glucokinase/AP-1 glucose transduction
mechanism in the ventromedial hypothalamic satiety center.
Frontiers in Diabetes 16: 313-326, 2004.
Mizuno, T.M., Funabashi, T., Kleopoulos,
S.P., Mobbs, C.V. Specific preservation of biosynthetic
responses to insulin in adipose tissue may contribute
to hyperleptinemia in insulin-resistant obese mice.
The Journal of Nutrition 134: 1045-1050, 2004.
Suyama, K., Daikoku, S., Funabashi,
T., Kimura, F. Effects of GABA and bicuculline
on the electrical activity of rat olfactory placode
neurons derived at E13.5 and cultured for 1 week on
multi-electrode dishes. Endocrine Journal 51:
171-176, 2004.
Funabashi, T., Kawaguchi, M., Furuta,
M., Fukushima, A., Kimura, F. Exposure to
bisphenol A during gestation and lactation causes loss
of sex difference in corticotropin-releasing hormone-immunoreactive
neurons in the bed nucleus of the stria terminalis of
rats. Psychoneuroendocrinology 29: 475-485,
2004.
Funabashi, T., Nakamura, T.J., Kimura,
F. p-Nonylphenol, 4-tert-octylphenol and bisphenol
A increase the expression of progesterone receptor mRNA
in the frontal cortex of adult ovariectomized rats.
Journal of Neuroendocrinology 16: 99-104, 2004.
Kimura, F., Shinohara, K., Funabashi,
T., Daikoku, S., Suyama, K., Mitsushima, D., Sano, A.
Nicotine inhibition of pulsatile GnRH secretion is mediated
by GABAA receptor system in the cultured rat embryonic
olfactory placode. Psychoneuroendocrinology
29: 749-756, 2004.
Masuda, J., Mitsushima, D., Kimura,
F. Female rats living in small cages respond to
restraint stress with both adrenocortical corticosterone
release and acetylcholine release in the hippocampus.
Neuroscience Letters 358: 169-172, 2004.
Mitsushima, D., Funabashi, T., Kimura,
F. Estrogen increases messenger RNA and immunoreactivity
of aryl-hydrocarbon receptor nuclear translocator 2
in the rat mediobasal hypothalamus. Biochemical
and Biophysical Research Communications 307: 248-253,
2003.
Mitsushima, D., Funabashi, T., Shinohara,
K., Kimura, F. Rats living in small cages respond
to restraint stress with adrenocortical corticosterone
release but not with hippocampal acetylcholine release.
Psychoneuroendocrinology 28: 574-583, 2003.
Funabashi, T., Sano, A., Mitsushima,
D., Kimura, F. Bisphenol A increases progesterone
receptor immunoreactivity in the hypothalamus in a dose-dependent
manner and affects sexual behaviour in adult ovariectomized
rats. Journal of Neuroendocrinology 15:
134-140, 2003.
Mitsushima D, Funabashi T, Shinohara
K, Kimura F. Rats living in small cages respond
to restraint stress with adrenocortical corticosterone
release but not with hippocampal acetylcholine release.
Psychoneuroendocrinology 28: 574-583, 2003.
Funabashi T, Sano A, Mitsushima D, Kimura
F. Bisphenol A increases progesterone receptor
immunoreactive cells in the hypothalamus in a dose-dependent
manner and affects sexual behavior in adult ovariectomized
rats. J Neuroendocrinology 15: 134-140,
2003.
Mitsushima D, Tin-Tin-Win-Shwe, Funabashi
T, Shinohara K, Kimura F. GABA release in the
medial preoptic area of cyclic female rats. Neuroscience
2002 Aug 2;113(1):109-114. PMID: 12123689
Shinohara K, Funabashi T, Nakamura TJ,
Mitsushima D, Kimura F. Differential regulation
of pituitary adenyl cyclase activating peptide receptor
variants in the rat suprachiasmatic nucleus. Neuroscience
2002;110(2):301-8. PMID: 11958871
Furuta M, Funabashi T, Kimura F.
Suppressive Action of Orexin A on Pulsatile Luteinizing
Hormone Secretion Is Potentiated by a Low Dose of Estrogen
in Ovariectomized Rats. Neuroendocrinology.
2002 Mar;75(3):151-157.
Furuta M, Funabashi T, Kimura F.
Intracerebroventricular administration of ghrelin rapidly
suppresses pulsatile luteinizing hormone secretion in
ovariectomized rats. Biochem Biophys Res Commun.
2001 Nov 9;288(4):780-5.
Nakamura TJ, Shinohara K, Funabashi
T, Kimura F. Effect of estrogen on the expression
of Cry1 and Cry2 mRNAs in the suprachiasmatic nucleus
of female rats. Neurosci Res. 2001 Nov;41(3):251-5.
Mitsushima D, He D, Funabashi T, Shinohara
K, Kimura F. Increase in the number of detectable
preoptic GAD67 immunoreactive cells in immature male
rats. Neurosci Res. 2001 May 40(2):141-146.
Mitsushima D, Funabashi T, Shinohara
K, Kimura F. Impairment of maze learning in rats
by restricting environmental space. Neurosci
Lett. 2001 Jan 12;297(2):73-6.
Funabashi T, Suyama K, Uemura T, Hirose
M, Hirahara F, Kimura F. Immortalized Gonadotropin-Releasing
Hormone Neurons (GT1-7 Cells) Exhibit Synchronous Bursts
of Action Potentials. Neuroendocrinology.
2001 Mar;73(3):157-165.
Shinohara K, Morofushi M, Funabashi
T, Kimura F. Axillary pheromones modulate pulsatile
LH secretion in humans. Neuroreport. 2001
Apr 17;12(5):893-5.
Funabashi T, Kleopoulos SP, Brooks PJ,
Kimura F, Pfaff DW, Shinohara K, Mobbs CV. Changes
in estrogenic regulation of estrogen receptor alpha
mRNA and progesterone receptor mRNA in the female rat
hypothalamus during aging: an in situ hybridization
study. Neurosci Res. 2000 Sep;38(1):85-92.
Shinohara K, Funabashi T, Mitushima
D, Kimura F. Effects of gap junction blocker on
vasopressin and vasoactive intestinal polypeptide rhythms
in the rat suprachiasmatic nucleus in vitro. Neurosci
Res. 2000 Sep;38(1):43-7.
Shinohara K, Morofushi M, Funabashi
T, Mitsushima D, Kimura F. Effects of 5alpha-androst-16-en-3alpha-ol
on the pulsatile secretion of luteinizing hormone in
human females. Chem Senses. 2000 Aug;25(4):465-7.
Morofushi M, Shinohara K, Funabashi
T, Kimura F. Positive relationship between menstrual
synchrony and ability to smell 5alpha-androst-16-en-3alpha-ol.
Chem Senses. 2000 Aug;25(4):407-11.
Funabashi T, Shinohara K, Mitsushima
D, Kimura F. Gonadotropin-releasing hormone exhibits
circadian rhythm in phase with arginine-vasopressin
in co-cultures of the female rat preoptic area and suprachiasmatic
nucleus. J Neuroendocrinol. 2000 Jun;12(6):521-8.
Shinohara K, Funabashi T, Mitushima
D, Kimura F. Effects of estrogen on the expression
of connexin32 and connexin43 mRNAs in the suprachiasmatic
nucleus of female rats. Neurosci Lett. 2000
Jun 2;286(2):107-10.
Funabashi T, Shinohara K, Mitsushima
D, Kimura F. Estrogen increases arginine-vasopressin
V1a receptor mRNA in the preoptic area of young but
not of middle-aged female rats. Neurosci Lett.
2000 May 19;285(3):205-8.
Saito K, Shinohara K, Morofushi M, Funabashi
T, Mitsushima D, Hata M, Matsubara S, Kimura F.
Effects of irradiation on the sensitivity of melatonin
release to norepinephrine in cultured pineal bodies
of rats. Neurosci Lett. 2000 Apr 21;284(1-2):93-6.
Funabashi T, Jinnai K, Sano A, Shinohara
K, Kimura F. Pentobarbital stimulates the activity
of the GnRH pulse generator interacting with opioid
neurons in rats in proestrus. Psychoneuroendocrinology.
2000 Apr;25(3):277-87.
Shinohara K, Hiruma H, Funabashi T,
Kimura F. GABAergic modulation of gap junction
communication in slice cultures of the rat suprachiasmatic
nucleus. Neuroscience. 2000;96(3):591-6.
Shinohara K, Uchiyama M, Okawa M, Saito
K, Kawaguchi M, Funabashi T, Kimura F. Menstrual
changes in sleep, rectal temperature and melatonin rhythms
in a subject with premenstrual syndrome. Neurosci
Lett. 2000 Mar 10;281(2-3):159-62.
He D, Mitsushima D, Uemura T, Hirahara
F, Funabashi T, Shinohara K, Kimura F. Effects
of naloxone on the serum luteinizing hormone level and
the number of Fos-positive gonadotropin-releasing hormone
neurons in immature female rats. Brain Res.
2000 Mar 6;858(1):129-35.
Funabashi T, Daikoku S, Shinohara K,
Kimura F. Pulsatile gonadotropin-releasing hormone
(GnRH) secretion is an inherent function of GnRH neurons,
as revealed by the culture of medial olfactory placode
obtained from embryonic rats. Neuroendocrinology.
2000 Feb;71(2):138-44.
Mitsushima D, Funabashi T, Kimura F.
Fos expression in gonadotropin-releasing hormone neurons
by naloxone or bicuculline in intact male rats.
Brain Res. 1999 Aug 21;839(1):209-12.
Sano A, Funabashi T, Kawaguchi M, Shinohara
K, Kimura F. Intravenous injections of nicotine
decrease the pulsatile secretion of LH by inhibiting
the gonadotropin-releasing hormone (GnRH) pulse generator
activity in female rats. Psychoneuroendocrinology.
1999 May;24(4):397-407.
Funabashi T, Aiba S, Sano A, Shinohara
K, Kimura F. Intracerebroventricular injection
of arginine-vasopressin V1 receptor antagonist attenuates
the surge of luteinizing hormone and prolactin secretion
in proestrous rats. Neurosci Lett. 1999
Jan 22;260(1):37-40.
He D, Funabashi T, Sano A, Uemura T,
Minaguchi H, Kimura F. Effects of glucose and
related substrates on the recovery of the electrical
activity of gonadotropin-releasing hormone pulse generator
which is decreased by insulin-induced hypoglycemia in
the estrogen-primed ovariectomized rat. Brain
Res. 1999 Feb 27;820(1-2):71-6.
Hla-Hla-Aye, Jinnai K, Sano A, Funabashi
T, Mitsushima D, Kimura F. Nicotine given intracerebroventricularly
does not inhibit the preovulatory surge of LH and PRL
secretion in female rats. Endocr J. 1998
Aug;45(4):575-80.
Shinohara K, Funabashi T, Kimura F.
Temporal profiles of vasoactive intestinal polypeptide
precursor mRNA and its receptor mRNA in the rat suprachiasmatic
nucleus. Brain Res Mol Brain Res. 1999
Jan 8;63(2):262-7.
Kawaguchi M, Funabashi T, Kimura F.
Insulin-induced hypoglycemia does not impair the surge
of luteinizing hormone secretion in the proestrous rat.
Neurosci Lett. 1998 Nov 13;256(3):131-4.
Funabashi T, Kleopoulos SP, Kimura F,
Mobbs CV. Changes in neurotensin mRNA by estrogen
in the female rat preoptic area during aging: an in
situ hybridization histochemistry study. Gen
Comp Endocrinol. 1998 Dec;112(3):364-71.
Funabashi T, Jinnai K, Kimura F.
Bicuculline infusion advances the timing of Fos expression
in LHRH neurons in the preoptic area of proestrous rats.
Neuroreport. 1997 Feb 10;8(3):771-4.
Funabashi T, Jinnai K, Kimura F.
Fos expression by naloxone in LHRH neurons of the mediobasal
hypothalamus and effects of pentobarbital sodium in
the proestrous rat. J Neuroendocrinol.
1997 Feb;9(2):87-92.
Funabashi T, Kimura F. The number
of luteinizing hormone-releasing hormone immunoreactive
neurons is significantly decreased in the forebrain
of old-aged female rats. Neurosci Lett.
1995 Apr 14;189(2):85-8.
Funabashi T, Hashimoto R, Jinnai K,
Kimura F. Microinjection of LHRH and its antagonistic
analog into the medial preoptic area does not affect
pulsatile secretion of LH in ovariectomized rats.
Endocr J. 1994 Oct;41(5):559-63.
Endo Y, Mizuno T, Fujita K, Funabashi
T, Kimura F. Soft-diet feeding during development
enhances later learning abilities in female rats.
Physiol Behav. 1994 Oct;56(4):629-33.
Funabashi T, Kimura F. Effects
of estrogen and estrogen receptor messenger RNA levels
in young and middle-aged female rats: comparison of
medial preoptic area and mediobasal hypothalamus.
Acta Biol Hung. 1994;45(2-4):223-31.
Kimura F, Jinnai K, Funabashi T.
A GABAB-receptor mechanism is involved in the prolactin
release in both male and female rats. Neurosci
Lett. 1993 Jun 11;155(2):183-6.
Kimura F, Sano A, Hiruma H, Funabashi
T. Effects of gamma-aminobutyric acid-A receptor
antagonist, bicuculline, on the electrical activity
of luteinizing hormone-releasing hormone pulse generator
in the ovariectomized rat. Neuroendocrinology.
1993 Apr;57(4):605-14.
Hashimoto R, Sano A, Nishimura J, Funabashi
T, Kimura F. Naloxone injected into the preoptic
region has hypophysiotropic and seizurogenic actions
in rats. Endocrinol Jpn. 1991 Jun;38(3):287-95.
Funabashi T, Hiruma H, Arita J, Kimura
F. Intraventricular injection of vasoactive intestinal
polypeptide facilitates the development of amygdaloid
kindling. Brain Res. 1991 Feb 8;541(1):110-4.
Kimura F, Nishihara M, Hiruma H, Funabashi
T. Naloxone increases the frequency of the electrical
activity of luteinizing hormone-releasing hormone pulse
generator in long-term ovariectomized rats. Neuroendocrinology.
1991 Jan;53(1):97-102. |